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Fig. 3 | Biology Direct

Fig. 3

From: Boanmycin overcomes bortezomib resistance by inducing DNA damage and endoplasmic reticulum functional impairment in multiple myeloma

Fig. 3

The inhibitory effect of boanmycin on BTZ-resistant multiple myeloma cells. (A) The cell viability assay was conducted to evaluate the sensitivity of RPMI 8226-Res and U266B1-Res cells, as well as the corresponding parental cell lines to BTZ. (B) The inhibitory effects of boanmycin on BTZ-resistant MM cells were assessed through CFSE staining. (C) Colonies were photographed and (D) counted after incubation of RPMI 8226-Res and U266B1-Res cells with different concentrations of boanmycin for 15 days. (E) Western blot analysis of proteins associated with cell apoptosis. (F) The level of apoptosis induced by boanmycin in BTZ-resistant MM cells was determined by flow cytometry. (mean ± SD, *p < 0.05, **p < 0.01 and ***p < 0.001)

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Biology Direct

ISSN: 1745-6150

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