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Fig. 5 | Biology Direct

Fig. 5

From: Bi-targeting of thioredoxin 1 and telomerase by thiotert promotes cell death of myelodysplastic syndromes and lymphoma

Fig. 5

Thiotert treatment induces MDS and lymphoma cell apoptosis. (A) Flow cytometric analysis showing apoptosis levels of SKM-1 and U-937 cells exposed to various concentrations of thiotert for 12 h. The quantification of apoptosis was displayed on the right. (B) Western blot analysis of apoptosis-related protein expression in SKM-1 and U-937 cells treated with different concentrations of thiotert for 12 h. (C-E) Histograms show densitometric analysis of apoptosis-related protein expression which were normalized to the β-actin. (F) Cell viability was analyzed under the treatment of thiotert with or without Z-VAD in SKM-1 cells. (G, H) Western blot analysis of apoptosis-related proteins under the treatment of thiotert with or without GSH (1 mM) and MitoQ (0.5 µM) in SKM-1 cells. *P < 0.05, **P < 0.01, ***P < 0.001

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