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Fig. 6 | Biology Direct

Fig. 6

From: Bi-targeting of thioredoxin 1 and telomerase by thiotert promotes cell death of myelodysplastic syndromes and lymphoma

Fig. 6

TERT or TRX1 overexpression enhances resistance to thiotert in SKM-1 cells. (A) Proliferation assay in SKM-1 cells with the overexpression of TERT or TRX1. (B) Cell viability upon thiotert treatment for 12 h in control, TERT, and TRX1 overexpressed SKM-1 cells. (C) Representative images of cytoplasm ROS or mitochondrial ROS levels induced by thiotert in control and TERT, TRX1 overexpressed SKM-1 cells. (D, E) Quantification data of cytoplasm ROS and mitochondrial ROS were shown. (F, G) Western blotting analysis of TERT, TRX1, and apoptosis-related protein expression under the treatment of thiotert in control, TERT, and TRX1 overexpressed SKM-1 cells. *P < 0.05, **P < 0.01, ***P < 0.001

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