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Fig. 7 | Biology Direct

Fig. 7

From: Bi-targeting of thioredoxin 1 and telomerase by thiotert promotes cell death of myelodysplastic syndromes and lymphoma

Fig. 7

Thiotert treatment suppresses the growth of SKM-1 cells in vivo. (A) The treatment schema for the tumor xenografts model in NSG mice. (B) The body weight after 20 mg/kg thiotert or 50 mg/kg cytarabine injection, i.p. every day for 7 days. (C) Representative images of fluorescence intensity upon 20 mg/kg thiotert or 50 mg/kg cytarabine treatment. (D) Flow cytometry analysis showing the number of GFP+/CD45+ cells in whole blood when treated with thiotert or cytarabine, quantification data were shown on the right. (E) H&E staining of liver and lung; IHC analysis for TRX1, TERT, and Ki67 in SKM-1 cell upon thiotert and cytarabine treatment. *P < 0.05, **P < 0.01

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