Fig. 4

FGI analysis of TCGA lung cancer RNA-Seq data. A t-SNE plot of annotated FGI gene clusters from TCGA LUAD and LUSC RNA-Seq data. Some annotations with long names are put outside the plot. Positional clusters are marked by the cluster number with additional letter “P”. B Distribution of positional clusters on the chromosome. C Venn diagram showing overlap of functional and positional clusters. D Consensus k-means clustering of LUAD and LUSC samples using 8 functional gene clusters. E FGI map with merged functions (see full image in Supplemental Fig. S1C). F Example of FGI mapping applied to two individual cases of tumor samples from LUAD and LUSC