Fig. 4
From: Matrix Metalloproteinase-9 is associated with tumor microenvironment remodeling of bladder cancer
Protein–protein interaction network (PPI), Cox analysis for DEGs, MMP9 expressions in different samples and their association with prognosis and clinical characteristics of BLC patients. (A) PPI generated using the nodes whose interaction confidence value were beyond 0.95. (B) Univariate Cox regression analysis for 528 DEGs, and the most significant genes were listed. (C) Venn plot indicating the genes in both the top 120 nodes from PPI and most significant genes in Cox regression. (D) MMP9 expressions in the samples from all normal and BLC tissues. (E) MMP9 expressions in the samples from both normal and BLC tissues in one patient. (F) Association between prognosis and MMP9 expressions in BLC patients by survival analysis. (F–K) The association between the expressions of MMP9 and gender, as well as staging characteristics in clinicopathology, using Wilcoxon rank sum or Kruskal–Wallis rank sum test to set the significance filtering threshold