Fig. 5

BRCA1 deletion activated p53/TGF-β signaling pathway. A KEGG analysis of all DEGs between the Control and BRCA1-/- groups. B–D Gene set enrichment analysis (GSEA) of RNA-seq data; note that the p53 signaling pathway, the TGF-β signaling pathway and protein processing in the endoplasmic reticulum were activated. E Expression level of DEGs enriched in the p53 (left) and TGF-β (right) signaling pathways. F–L Evaluation of relative expression levels of CDK1, CDK2, CCNB1, CCNB2, CDKN2A, CDKN1A and Fas mRNA; data are shown as the mean ± SEM, n = 3, *p < 0.05, ****p < 0.0001