Fig. 7

Hypothetical drawing of the molecular mechanism underlying the roles of BRCA1 in the regulation of rapid antler regeneration and genomic stability. During antler regeneration, rapid cell proliferation tends to cause increased DNA damage stress and ER stress. High expression of BRCA1, on the one hand, may regulate DNA damage response by promoting HR repair, and on the other hand, may inhibit p53/TGF/ER stress-induced cell death, such that cells that have their genomic stability restored continue to enter rapid proliferation mode