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Fig. 3 | Biology Direct

Fig. 3

From: Fraxinellone-mediated targeting of cathepsin B leakage from lysosomes induces ferroptosis in fibroblasts to inhibit hypertrophic scar formation

Fig. 3

FRA activated ferroptosis in HSFs. (A) Schematic illustration of the experimental design and the process of HSFs preparation for ONT long-read RNA-seq. (B) KEGG pathway enrichment analysis of the DEGs between the CTL and FRA (300 µM for 48 h)-treated groups. The red boxes indicate the signalling pathways of interest. (C) GO analysis of the DEGs in different groups. The red boxes indicate the signalling pathways of interest. (D) GSEA plot of the ferroptosis pathway based on ONT long-read RNA-seq. (E) Heatmap of ferroptosis-related DEGs between the CTL and FRA-treated groups. Red: high expression levels. Blue: low expression levels. (F) Chord graph of the relationships between the DEGs and enrichment pathways

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Biology Direct

ISSN: 1745-6150

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