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Fig. 8 | Biology Direct

Fig. 8

From: Fraxinellone-mediated targeting of cathepsin B leakage from lysosomes induces ferroptosis in fibroblasts to inhibit hypertrophic scar formation

Fig. 8

Schematic illustration of the study. (A) FRA affects fibroblasts behaviour by inducing ferroptosis to ameliorate hypertrophic scar. (B) ONT long-read RNA-seq reveals that FRA induces ferroptosis of fibroblasts by CTSB. (C) FRA can mediate CTSB leakage from lysosomes in fibroblasts, and CTSB induces ferroptosis via SAT1-mediated lipid peroxidation, mitochondrial damage and MAPK signalling pathway activation. Schematic plots were created in BioRender.com

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Biology Direct

ISSN: 1745-6150

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