Fig. 4
From: Oncogenic RIT1 mutations confer ferroptosis vulnerability in lung adenocarcinoma
Transcriptomic profiling of cells expressing RIT1 wild-type and oncogenic mutations. (A) Principal component (PC) analysis of RNA-seq data for control vector (pCDH), WT (wild-type) and mutant groups. (B) Heat map illustrating differentially-expressed genes (DEGs) among 5 groups as indicated. (C and D) GO (Gene Ontology) and KEGG (Kyoto Encyclopedia of Genes and Genomes) enrichment analysis of DEGs between WT RIT1 and mutant groups. (E) Oncogenic signature enrichment analysis of DEGs between WT RIT1 and mutant groups