Skip to main content
Fig. 1 | Biology Direct

Fig. 1

From: Sigma-1 receptor activation attenuates DOX-induced cardiotoxicity by alleviating endoplasmic reticulum stress and mitochondrial calcium overload via PERK and IP3R-VDAC1-MCU signaling pathways

Fig. 1

Flv and BD1047 can effectively activate and inhibit S1R, but injection of Flv and BD1047 into normal control mice does not affect cardiac function. A HE staining showed that injection of Flv and BD1047 into normal mice had no effect on the arrangement of myocardial fibers. B–D Echocardiography showed no significant differences in ejection fraction and cardiac function of mice injected with Flv and BD1047 compared with normal mice (n = 3). E Immunofluorescence showed that S1R could be effectively activated or inhibited by Flv and BD1047 (n = 3). F Western blot showed that injection of Flv and BD1047 into normal mice had no significant effect on apoptosis-related proteins. G The statistical analysis diagrams of immunofluorescence staining reflecting S1R expression (n = 3). H The statistical analysis diagrams of Bcl2, Bax protein level relative to GAPDH (n = 3). *p < 0.05; ***p < 0.005; ****p < 0.001

Back to article page

Biology Direct

ISSN: 1745-6150

Contact us