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Fig. 4 | Biology Direct

Fig. 4

From: Sigma-1 receptor activation attenuates DOX-induced cardiotoxicity by alleviating endoplasmic reticulum stress and mitochondrial calcium overload via PERK and IP3R-VDAC1-MCU signaling pathways

Fig. 4

Activation of S1R attenuates oxidative stress levels and mitigates mitochondrial damage in mouse heart. A, B DHE showed that activation of S1R attenuated ROS production in myocardial tissue (n = 3). C TEM detection showed activation of S1R improved mitochondrial morphology and attenuated mitochondrial injury. D, E Activation of S1R inhibited PERK and IP3R-VDAC1-MCU signaling pathways and alleviated endoplasmic reticulum stress and mitochondrial damage (n = 3). *:p < 0.05; **p < 0.01; ***p < 0.005; ****p < 0.001

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