Fig. 5
From: Doxorubicin PK/PD modeling in multiple myeloma: towards in silico trials
Example of PK/PD simulation. 3 experiments were simulated to compare the efficacy of single bolus high DOXO treatments vs a multi-bolus low DOXO treatment. The upper panels shows the total intracellular DOXO, sum of the DNA-bound and the cytosolic DOXO. The middle panes show a zoom around the first DOXO bolus and the DNA-bound DOXO over time respectively. The lower panel reports the PD simulation results with the number of living simulated cells over time