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Fig. 6 | Biology Direct

Fig. 6

From: Single-cell RNA sequencing reveals a new mechanism of endothelial cell heterogeneity and healing in diabetic foot ulcers

Fig. 6

SH3BGRL3 promotes angiogenesis, proliferation, and migration of HUVECs under high-glucose conditions. A, B Wound healing assays indicating that overexpression of SH3BGRL3 upregulated the motility of HUVECs. C, D EdU incorporation assays to evaluate DNA synthesis in HUVECs. Red fluorescence represents EdU-positive cells, and blue fluorescence represents total cells. Representative images and quantitative analysis of the EdU assay. E, F Representative images and quantitative analysis of HUVEC transwell migration assays. G, H Tube formation assays and quantitative analysis of HUVECs (branch points and tube length). HG = High-glucose conditions; NC = Normal control. Data are presented as mean values ± SD, n = 3, *** P < 0.001

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