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Fig. 8 | Biology Direct

Fig. 8

From: Exploring the mechanisms of PANoptosis in osteoarthritis and the therapeutic potential of andrographolide through bioinformatics and single-cell analysis

Fig. 8

Analysis of PANoptosis Hub Genes in Osteoarthritis Cartilage Cells. A, B Monocle2 trajectory analysis showing the pseudotime ordering of cells in both control and osteoarthritis (OA) cartilage samples. C Proportional abundance of different cell subpopulations within the OA cartilage tissue, highlighting shifts in cell population distribution compared to control samples. D Differential expression analysis using the SCDE package. The analysis identifies significantly upregulated PANoptosis hub genes, including CASP8, CASP1, TLR3, and IL18, in OA cartilage cells, indicating their potential involvement in disease progression. E Expression patterns of specific genes within the identified cell subpopulations, emphasizing the localization and levels of PANoptosis-related genes across different cell clusters

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Biology Direct

ISSN: 1745-6150

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