Fig. 1
From: Lipidome atlas of p53 mutant variants in pancreatic cancer
p53 silencing remodels the lipidome of pancreatic cancer cells. A, B Volcano plots and heat-maps were obtained from all identified lipid compounds in KPC cells expressing p53R172H or p53R270H following transfection with siRNA Control or siRNA against p53. Heat maps of endogenous metabolites between control groups and sip53 (n = 5). In the heat map, red-filled and bleu-filled lines indicate increased or decreased levels of lipids, respectively. C Western blot analysis reports silencing efficiency of p53 mutants in KPC cells following transfection of siRNA Control or siRNA against p53. D–F Box plots show the significantly modulated lipid entities after p53 mutant knockdown. *p value < 0.05; **p value < 0.01; ***p value < 0.001; ****p value < 0.0001. p value was calculated by unpaired two-sample t-test