Fig. 4
From: Deubiquitination of DNM1L by USP3 triggers the development and metastasis of gallbladder carcinoma
DNM1L promoted carcinogenesis of GBC cells and liver metastasis in mice. a The flow diagram showed the main operation and time for the cell-derived xenograft model and splenic injection liver metastasis experiment. b The xenografts from the mice injected with NOZ cells were collected and their volumes were calculated. c IHC staining showed the expression of Ki67 in different tumor sections. d TUNEL staining of tumor xenograft sections. e Representative images of luciferase signals in mice at 28 days after intrasplenic injection with NOZ cells. f Representative livers were shown and black arrows indicated the metastasis nodules. g Metastatic nodules were counted in the intrasplenic injection model. (h) HE staining detected the tumor cells in the live sections. n = 5 per group.**p < 0.01, ***p < 0.001