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Fig. 4 | Biology Direct

Fig. 4

From: Large-scale bulk and single-cell RNA sequencing combined with machine learning reveals glioblastoma-associated neutrophil heterogeneity and establishes a VEGFA+ neutrophil prognostic model

Fig. 4

Comprehensive map of the gene regulatory networks in GBMAN subtypes. (A) The boxplot compares the genomic instability scores across different subgroups, reflecting the extent of genomic alterations in four GBMAN subpopulations. (B) PCA plot visualizing the activity patterns of TFs across various neutrophil subpopulations. The plot highlights distinct clusters based on TF activity, revealing key regulatory differences between subgroups and their potential roles in functional diversity. (C) Specific TFs of various neutrophil subpopulations in the primary and recurrent groups. (D-G) The left figure shows the GSEA enrichment analysis of differences between different neutrophil subpopulations in primary and recurrent cases, while the right figure presents the gene regulatory network of each pathway

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Biology Direct

ISSN: 1745-6150

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