Fig. 1
From: GAMT facilitates tumor progression via inhibiting p53 in clear cell renal cell carcinoma
GAMT is highly expressed in ccRCC and correlated with poor prognosis. (A) Metabolomics flow chart and heatmap of the differential metabolites at the early (upper) and advanced tumor stages (lower). (B) Venn diagram shows the significantly enriched pathways. (C) Heatmap overview of differentially expressed genes in creatine metabolism. D, E. qPCR (D) and Western blot (E) analyses of GAMT in early-stage tissues. F, G. qPCR (F) and Western blot (G) analyses of GAMT in advanced-stage tissues. H, I. Representative IHC images of GAMT in normal and ccRCC tissues from clinical tissue microarray (H); Comparation of histoscore between normal and tumor tissues (I). J. K-M curves for overall survival of ccRCC patients from high histoscore group and low histoscore group. K, L. Kaplan–Meier curves for overall survival of patients with ccRCC from the ICGC (left) and GEO (right) databases. *** p < 0.001