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Fig. 6 | Biology Direct

Fig. 6

From: ELK4 induced upregulation of HOMER3 promotes the proliferation and metastasis in glioma via Wnt/β-catenin/EMT signaling pathway

Fig. 6

Role of HOMER3 in glioma metastasis via the Wnt/β-catenin/EMT pathway. (A-B) Transwell assays assessing migration and invasion capabilities of U251 and U87 cells post-HOMER3 knockdown, revealing significant suppression of both. (C-E) Correlation analyses demonstrating associations between HOMER3 expression and key biomarkers in the Wnt/β-catenin signaling pathway and epithelial-mesenchymal transition (EMT). (F) Western blotting results confirming the impact of HOMER3 knockdown on the expression of β-catenin, N-cadherin, and EMT markers, reinforcing the role of HOMER3 in promoting glioma metastasis through the modulation of the Wnt/β-catenin/EMT pathway. All experiments were performed in three independent biological replicates (n = 3) to ensure the reproducibility and reliability of the results

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Biology Direct

ISSN: 1745-6150

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