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Fig. 1 | Biology Direct

Fig. 1

From: Gliadin-dependent UPR induction directly triggers the expression of TG2 and pro-inflammatory cytokines, dysregulates intestinal permeability, and reduces CFTR expression in intestinal epithelial cells of celiac disease patients

Fig. 1

PT stimulated ER stress induction in CD patients and mice gut tissue. Gut biopsies from 8 non-CD (NCD) and 9 CD pediatric patients were collected and the expression of TG2 (A), CXCR3 (B, left panel), CXCR3 (B, right panel) CLD-2, CLD-15 and OCL (C), IFNγ, IL15, IL17A (D), ATF4, ATF6, and XBP1s (E) was evaluated by qPCR and reported in the corresponding box plot

S.i. from GF mice was untreated or exposed to PT (5 mg/mL) for 9 h, in GEVS. Tissue distribution of the ER stress marker eIF2α-P was evaluated (red) in IEC evidenced by the anti-E-Cadherin (green), while nuclei were stained by DAPI (blue; F). Representative images of experiment performed in triplicate; scale bar = 10 μm

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ISSN: 1745-6150

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