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Fig. 6 | Biology Direct

Fig. 6

From: Gliadin-dependent UPR induction directly triggers the expression of TG2 and pro-inflammatory cytokines, dysregulates intestinal permeability, and reduces CFTR expression in intestinal epithelial cells of celiac disease patients

Fig. 6

PT-induced UPR also regulates inflammation and gut permeability mainly through NF-kB. CaCo-2 cells were unexposed or exposed 9 h to PT (1 mg/mL) alone or in combination with BAPTA-AM (BAPTA, 10 µM; 1 h pretreatment) and BAY11-7082 (BAY, 5 µM; 1 h pretreatment), and the expression of the indicated pro-inflammatory cytokines (A) or tight junction proteins (B) was evaluated by qPCR. (C) A schematic representation of the signaling pathway by which PT stimulates the activation of the transcription factor NF-kB and the downstream inflammatory cytokines expression/production and TJs function/expression, in IECs

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ISSN: 1745-6150

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