Fig. 5
From: CAP1: a novel extracellular vesicle marker linked to endothelial senescence in atherosclerosis
EVs from aged ApoE knockout mice induce ES in WT animals. A. Representative immunoblot detection of CAP1 from blood circulating EVs isolated from young and aged ApoE knockout mice (N = 3 Mean ± SD. *p < 0.05 Young vs. Aged ApoE EVs). B-E. Hematoxylin/Eosin (H&E) staining (upper panels) and b-Galactosidase (b-Gal) assay (lower panels) in aortic sections of WT mice fed with regular diet (B, C) or high-fat diet (D, E), and injected with EVs from young (B, D), or aged (C, E) ApoE KO mice as indicated. Scale bars 100 μm (N = 3/group)