Fig. 6
From: CAP1: a novel extracellular vesicle marker linked to endothelial senescence in atherosclerosis
EVs from aged ApoE knockout mice induce ES and extensive atheroma plaque formation in young ApoE null mice. Hematoxylin/Eosin (H&E) staining (upper), β-Gal assay (lower left), and Von Kossa staining (lower right) in aortic sections of young ApoE knockout mice injected with EVs from young (upper panels) or aged (lower panels) ApoE KO mice. (Mean ± SD. N = 3/group *p < 0.05 EVs from aged vs. EVs from young ApoE KO mice). Orange arrows show atheromatous plaque thickness. White arrows indicate arterial medial thickness. Black arrows show intraplaque calcium deposits