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Fig. 1 | Biology Direct

Fig. 1

From: The role of IGF2BP2 in macrophage-mediated NLRP3 inflammasome activation in the pathogenesis of dry AMD

Fig. 1

IGF2BP2 participates in the disease progression of dry AMD (A) the expression of IGF2BP2 protein in retinal choroid tissue after NaIO3 treatment. (B) The expression of IGF2BP2 mRNA in retinal choroid tissue after NaIO3 treatment. P = 0.0016 (C) Thickness of the ONL. (D) H&E staining revealed the histopathological changes in the retinas of WT and IGF2BP2-/- mice, both in normal controls and 7 days after NaIO3 administration. (E-F) Representative fundus images, SD-OCT images and a spider plot showing changes structure and thickness of fundus retina, keeping the optic nerve head (ONH) as the center position. (G) Amplitudes of the a- waves and b-waves. (H) Representative electroretinogram (ERG) of 24-hour dark adaptation mice. ONL outer nuclear layer; OPL outer plexiform layer. * P < 0.05, ** P < 0.01. Data are the means ± SEM. Data are representative of results obtained from six mice in each group (n = 6)

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