Fig. 1

Prmt1 were upregulated in CHOM mice. (A) Schematic models of CHOM mice. (B-D) Serum concentrations of IL-1β (B), IL-6 (C), and TNF-α (D) in Control and CHOM mice (n = 8 per group). (E) Representative images of inflammatory lesions in tibiae from Control and CHOM mice. (F) Representative images of H&E staining in tibiae from Control and CHOM mice. Asterisks (*) indicated areas of sequestrum formation. (G) Bacterial CFU numbers in Control and CHOM mice. Homogenates prepared from 1 g of tibiae from each group of mice were plated onto Tryptic Soy Agar (TSA) plates. The plates were incubated at 37 °C for 20 h, and the resulting colonies were counted. (H-P) mRNA levels of Prmt1-9 in Control and CHOM mice (n = 8 per group). (H)Prmt1; (I)Prmt2; (J)Prmt3; (K)Prmt4; (L)Prmt5; (M)Prmt6; (N)Prmt7; (O)Prmt8; (P)Prmt9. (Q) Protein levels of Prmt1-9 in the tibiae tissues from Control and CHOM mice (n = 3 per group). ns: no significant difference; **P < 0.01; ***P < 0.001