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  1. Laryngeal carcinoma (LC) is a common cancer of the respiratory tract. This study aims to investigate the role of RNA-binding motif protein 15 (RBM15) in the cisplatin (DDP) resistance of LC cells. LC-DDP-resis...

    Authors: Yue Liang, Haoyue Zhong, Yi Zhao, XiaoMin Tang, Chunchen Pan, Jingwu Sun and Jiaqiang Sun
    Citation: Biology Direct 2024 19:57
    Content type: Research Published on:

  2. Neuroendocrine prostate cancer (NEPC), a lethal subset of prostate cancer (PCa), is characterized by loss of AR signaling and resistance to AR-targeted therapy. While it is well reported that second-generation...

    Authors: Nan Jing, Zhenkeke Tao, Xinxing Du, Zhenzhen Wen, Wei-Qiang Gao, Baijun Dong and Yu-Xiang Fang
    Citation: Biology Direct 2024 19:56
    Content type: Research Published on:

  3. Ubiquitinylation of protein substrates results in various but distinct biological consequences, among which ubiquitin-mediated degradation is most well studied for its therapeutic application. Accordingly, art...

    Authors: Tatyana A. Grigoreva, Daria S. Novikova, Gerry Melino, Nick A. Barlev and Vyacheslav G. Tribulovich
    Citation: Biology Direct 2024 19:55
    Content type: Review Published on:

  4. Retinal vascular endothelial cell (RVECs) injury is a major cause of morbidity and mortality among the patients with diabetes. RVECs dysfunction is the predominant pathological manifestation of vascular compli...

    Authors: Qi Zhou, Min Tian, Yang Cao, Min Tang, Xiaohong Xiang, Lu Guo and Hongbin Lv
    Citation: Biology Direct 2024 19:54
    Content type: Research Published on:

  5. Hepatocellular carcinoma (HCC) ranks as the second leading cause of global cancer-related deaths and is characterized by a poor prognosis. Eukaryotic translation elongation factor 1 alpha 1 (EEF1A1) have been ...

    Authors: Jie Zhao, Qiang Huo, Ji Zhang, Kexiang Sun, Jinhui Guo, Feng Cheng, Xiaoge Hu and Qiuran Xu
    Citation: Biology Direct 2024 19:53
    Content type: Research Published on:

  7. Esophageal carcinoma (EC) and gastric cardiac adenocarcinoma (GCA) have high incidence rates in the Chaoshan region of South China. Multifocal esophageal and cardiac cancer (MECC) is commonly observed in this ...

    Authors: Xi Liu, Lijun Cai, Juan Ji, Dongping Tian, Yi Guo, Shaobin Chen, Meng Zhao and Min Su
    Citation: Biology Direct 2024 19:51
    Content type: Research Published on:

  8. Prostate cancer (PCa) is the second leading cause of tumor-related mortality in men. Metastasis from advanced tumors is the primary cause of death among patients. Identifying novel and effective biomarkers is ...

    Authors: YaXuan Wang, Bo Ji, Lu Zhang, Jinfeng Wang, JiaXin He, BeiChen Ding and MingHua Ren
    Citation: Biology Direct 2024 19:50
    Content type: Research Published on:

  9. Most patients with acute myeloid leukemia (AML) eventually develop drug resistance, leading to a poor prognosis. Dysregulated long gene non coding RNAs (lincRNAs) have been implicated in chemoresistance in AML...

    Authors: Yue Liu, Xiao-ya Zhu, Li-li Liao, Zhan-hui Zhang, Tao-sheng Huang, Ling Zhang, Xi-wen Jiang and Yi Ma
    Citation: Biology Direct 2024 19:49
    Content type: Research Published on:

  10. Prior research has highlighted the involvement of a transcriptional complex comprising C-terminal binding protein 2 (CtBP2), histone acetyltransferase p300, and nuclear factor kappa B (NF-κB) in the transactiv...

    Authors: Fan Li, Wenqing Yan, Weihua Dong, Zhiping Chen and Zhi Chen
    Citation: Biology Direct 2024 19:48
    Content type: Research Published on:

  11. Long noncoding RNAs (lncRNAs) are implicated in the initiation and progression of diffuse large B-cell lymphoma (DLBCL). Small nucleolar RNA host gene 20 (SNHG20) has been recognized as a critical lncRNA in mu...

    Authors: Chaoyu Wang, Wen Fu, Youju Zhang, Xiaoge Hu, Qiuran Xu and Xiangmin Tong
    Citation: Biology Direct 2024 19:47
    Content type: Research Published on:

  13. Glioma is a common tumor that occurs in the brain and spinal cord. Hypoxia is a crucial feature of the tumor microenvironment. Tumor-associated macrophages/microglia play a crucial role in the advancement of g...

    Authors: Jinchao Si, Jingya Guo, Xu Zhang, Wei Li, Shen Zhang, Shuyu Shang and Quanwu Zhang
    Citation: Biology Direct 2024 19:45
    Content type: Research Published on:

  14. The molecular mechanisms of osteosarcoma (OS) are complex. In this study, we focused on the functions of melanoma cell adhesion molecule (MCAM), methyltransferase 3 (METTL3) and insulin like growth factor 2 mR...

    Authors: Dongjian Song, Qi Wang, Zechen Yan, Meng Su, Hui Zhang, Longyan Shi, Yingzhong Fan, Qian Zhang, Heying Yang, Da Zhang and Qiuliang Liu
    Citation: Biology Direct 2024 19:44
    Content type: Research Published on:

  16. Triple-negative breast cancer (TNBC) is more aggressive and has a higher metastasis rate compared with other subtypes of breast cancer. Due to the lack of drug-targetable receptors, chemotherapy is now the onl...

    Authors: Yuxiang Lin, Yan Li, Xiaobin Chen, Xuan Jin, Meichen Jiang, Han Xiao, Lili Chen, Minyan Chen, Wenzhe Zhang, Hanxi Chen, Qian Nie, Rongrong Guo, Wenhui Guo, Fangmeng Fu and Chuan Wang
    Citation: Biology Direct 2024 19:42
    Content type: Research Published on:

  17. The enzymes performing protein post-translational modifications (PTMs) form a critical post-translational regulatory circuitry that orchestrates literally all cellular processes in the organism. In particular,...

    Authors: Alexandra Daks, Sergey Parfenyev, Oleg Shuvalov, Olga Fedorova, Alexander Nazarov, Gerry Melino and Nickolai A. Barlev
    Citation: Biology Direct 2024 19:41
    Content type: Review Published on:

  19. The presence of mesenchymal stem cells has been confirmed in some solid tumors where they serve as important components of the tumor microenvironment; however, their role in cancer has not been fully elucidate...

    Authors: Xiaoyan Gao, He Ren, Zhengrong Zhang, Shuai Cao, Bo Zhang, Qiang Sun, Gerry Melino and Hongyan Huang
    Citation: Biology Direct 2024 19:39
    Content type: Research Published on:

  20. Clear cell renal cell carcinoma (ccRCC) is the most common subtype of RCC with high rates of metastasis. Targeted therapies such as tyrosine kinase and checkpoint inhibitors have improved treatment success, bu...

    Authors: Konrad Grützmann, Karsten Salomo, Alexander Krüger, Andrea Lohse-Fischer, Kati Erdmann, Michael Seifert, Gustavo Baretton, Daniela Aust, Doreen William, Evelin Schröck, Christian Thomas and Susanne Füssel
    Citation: Biology Direct 2024 19:38
    Content type: Research Published on:

  22. Epidermal growth factor receptor (EGFR)-targeted therapy is an important treatment for RAS wild-type metastatic colorectal cancer (mCRC), but the resistance mechanism remains unclear. Here, the differential ex...

    Authors: Yiting Geng, Xiao Zheng, Dachuan Zhang, Shanshan Wei, Jun Feng, Wei Wang, Luo Zhang, Changping Wu and Wenwei Hu
    Citation: Biology Direct 2024 19:36
    Content type: Research Published on:

  23. Ubiquitin-conjugating enzyme E2 N (UBE2N) is recognized in the progression of some cancers; however, little research has been conducted to describe its role in prostate cancer. The purpose of this paper is to ...

    Authors: Bo Yang, Weihua Chen, Tianyi Tao, Jun Zhang, Dehui Kong, Jidong Hao, Chao Yu, Guoqiang Liao and Hua Gong
    Citation: Biology Direct 2024 19:35
    Content type: Research Published on:

  24. LncRNA PCED1B-AS1 is abnormally expressed in multiple cancers and has been confirmed as an oncogene. Our study aimed to investigate the regulatory mechanism of lncRNA PCED1B-AS1 in gastric cancer.

    Authors: Jia Cao, Yicheng Yang, Bensong Duan, Haibin Zhang, Qinwei Xu, Junyi Han and Bing Lu
    Citation: Biology Direct 2024 19:34
    Content type: Research Published on:

  25. The Advanced Plant Experiment-04 - Epigenetic Expression (APEX-04-EpEx) experiment onboard the International Space Station examined the spaceflight-altered cytosine methylation in two genetic lines of Arabidopsis...

    Authors: Mingqi Zhou, Alberto Riva, Marie-Pierre L. Gauthier, Michael P. Kladde, Robert J. Ferl and Anna-Lisa Paul
    Citation: Biology Direct 2024 19:33
    Content type: Research Published on:

  26. Doxorubicin (Dox) is associated with various liver injuries, limiting its clinical utility. This study investigates whether NSUN2 participates in Dox-induced liver injury and the associated molecular mechanism.

    Authors: Yingying Huang, Xiao Li, Lin Wei, Shinan Ma, Liming Ma, Yuxin Zan, Xiju He, Yijun Tang and Yan Ding
    Citation: Biology Direct 2024 19:32
    Content type: Research Published on:

  27. Deubiquitinating enzymes (DUBs) cleave ubiquitin on substrate molecules to maintain protein stability. DUBs reportedly participate in the tumorigenesis and tumour progression of hepatocellular carcinoma (HCC)....

    Authors: Yingnan Yang, Siying Jia, Ning Zhu, Xuelian Xiao, Ying Ma, Kangsheng Tu, Yong Guo and Qiuran Xu
    Citation: Biology Direct 2024 19:31
    Content type: Research Published on:

  28. Large bone defects pose a clinical treatment challenge; inhibiting transferrin receptor 2 (TfR2), which is involved in iron metabolism, can promote osteogenesis. Iron-based metal-organic frameworks (MOF-Fe) pa...

    Authors: Yaxin Xue, Wei Xu, Danyang Zhao, Zijing Du, Hao Jiang, Hao Lv, Dong Zhang, Zhencheng Yu, Yi Cao and Dong Han
    Citation: Biology Direct 2024 19:30
    Content type: Research Published on:

  29. Oocyte quality is critical for the mammalian reproduction due to its necessity on fertilization and early development. During aging, the declined oocytes showing with organelle dysfunction and oxidative stress...

    Authors: Lin-Lin Hu, Mei-Hua Liao, Ya-Xi Liu, Chun-Hua Xing, Lan-Lan Nong, Feng-Lian Yang and Shao-Chen Sun
    Citation: Biology Direct 2024 19:29
    Content type: Research Published on:

  30. Osteosarcoma is a diverse and aggressive bone tumor. Driver genes regulating osteosarcoma initiation and progression remains incompletely defined. Zinc finger protein 692 (ZNF692), a kind of Krüppel C2H2 zinc ...

    Authors: Di Zheng, Zhun Wei, Chong Zhang, Wenda Liu, Changtian Gong, Fei Wu and Weichun Guo
    Citation: Biology Direct 2024 19:28
    Content type: Research Published on:

  32. Ischemic stroke is a sudden and acute disease characterized by neuronal death, increment of reactive gliosis (reactive microglia and astrocytes), and a severe inflammatory process. Neuroinflammation is an earl...

    Authors: Mario Villa-González, Marina Rubio, Gerardo Martín-López, Paula R. Mallavibarrena, Laura Vallés-Saiz, Denis Vivien, Francisco Wandosell and Maria José Pérez-Álvarez
    Citation: Biology Direct 2024 19:26
    Content type: Research Published on:

  33. Circular RNAs (circRNAs) are a class of highly multifunctional single-stranded RNAs that play crucial roles in cancer progression, including osteosarcoma (OS). Circ_0002669, generated from the dedicator of cyt...

    Authors: Ying Zhang, Yizhou Zhan, Zhaoyong Liu, Huancheng Guo, Dongchen Liu and Chuangzhen Chen
    Citation: Biology Direct 2024 19:25
    Content type: Research Published on:

  34. Pancreatic cancer stem cells are crucial for tumorigenesis and cancer metastasis. Presently, long non-coding RNAs were found to be associated with Pancreatic Ductal Adenocarcinoma stemness characteristics but ...

    Authors: Zhenchong Li, Zuyi Ma, Shujie Wang, Qian Yan, Hongkai Zhuang, Zixuan Zhou, Chunsheng Liu, Yubin Chen, Mingqian Han, Zelong Wu, Shanzhou Huang, Qi Zhou, Baohua Hou and Chuanzhao Zhang
    Citation: Biology Direct 2024 19:24
    Content type: Research Published on:

  35. This study seeks to investigate the impacts of Lactobacillus reuteri (L. reuteri) on hepatic ischemia-reperfusion (I/R) injury and uncover the mechanisms involved.

    Authors: Leiyi Zhang, Xiaoxiang Gong, Juan Tan, Rongsen Zhang, Mingxia Li, Cong Liu, Chenhao Wu and Xiaojing Li
    Citation: Biology Direct 2024 19:23
    Content type: Research Published on:

  36. Neutral/alkaline invertases (N/AINVs) play a crucial role in plant growth, development, and stress response, by irreversibly hydrolyzing sucrose into glucose and fructose. However, research on cotton in this a...

    Authors: Kaikai Qiao, Qingtao Zeng, Jiaoyan Lv, Lingling Chen, Juxin Hao, Ding Wang, Qifeng Ma and Shuli Fan
    Citation: Biology Direct 2024 19:22
    Content type: Research Published on:

  37. Mammalian enabled (MENA) protein is a member of the enabled/vasodilator stimulated phosphoprotein (Ena/VASP) protein family, which regulates cytoplasmic actin network assembly. It plays a significant role in b...

    Authors: Lifang He, Chuanghong She, Sen Jiang, Zhaochang Qi, Zihao Deng, Likeng Ji, Yukun Cui and Jundong Wu
    Citation: Biology Direct 2024 19:21
    Content type: Research Published on:

  38. CircLRIG1, a newly discovered circRNA, has yet to have its potential function and biological processes reported. This study explored the role of circLRIG1 in the development and progression of bladder carcinoma a...

    Authors: Shiliang Cheng, Chunguang Li, Lu Liu, Xinli Liu, Meng Li, Jinhua Zhuo, Jue Wang, Wen Zheng and Zhongmin Wang
    Citation: Biology Direct 2024 19:20
    Content type: Research Published on:

  39. Esophageal squamous cell carcinoma (ESCC) is the main subtype of esophageal cancer. Current therapeutic effect is far from satisfaction. Hence, identifying susceptible genes and potential targets is necessary ...

    Authors: Zhiwei Chang, Yongxu Jia, Ming Gao, Lijie Song, Weijie Zhang, Ruihua Zhao, Dandan Yu, Xiaolei Liu, Jing Li and Yanru Qin
    Citation: Biology Direct 2024 19:19
    Content type: Research Published on:

  40. STAM Binding Protein Like 1 (STAMBPL1), functions as a deubiquitinase (DUB) and plays a significant role in various types of cancers. However, its effect as a DUB participating in the HCC tumorigenesis and pro...

    Authors: Zhihuai Wang, Yinjie Zhang, Yuhang Shen, Haiyang Zhou, Yuan Gao, Chunfu Zhu and Xihu Qin
    Citation: Biology Direct 2024 19:18
    Content type: Research Published on:

  41. Bladder cancer (BC) is the fourth and tenth most common malignancy in men and women worldwide, respectively. The complexity of the molecular biological mechanism behind BC is a major contributor to the lack of...

    Authors: Du Shen and Shaosan Kang
    Citation: Biology Direct 2024 19:17
    Content type: Research Published on:

    The Correction to this article has been published in Biology Direct 2024 19:27

  42. Cholangiocarcinoma (CCA) is a biliary epithelial malignant tumor with an increasing incidence worldwide. Therefore, further understanding of the molecular mechanisms of CCA progression is required to identify ...

    Authors: Chengshuo Zhang, Yu Wang, Gang Wu, Ning Sun, Han Bai, Xuejian Li, Shuai Han, Haonan Zhou, Ruizhao Qi and Jialin Zhang
    Citation: Biology Direct 2024 19:16
    Content type: Research Published on:

  43. Lenvatinib is an oral small molecule inhibitor approved for treating patients with unresectable hepatocellular carcinoma (HCC) worldwide. Increasing cell sensitivity to lenvatinib would be an effective method ...

    Authors: Yarong Guo, Bao Chai, Hezhao Zhang, Xinhao Chai, Yan Chen, Jun Xu, Liwei Qin and Yuting Chai
    Citation: Biology Direct 2024 19:15
    Content type: Research Published on:

  45. Hepatocellular carcinoma (HCC) is a prevalent malignant tumor that poses a major threat to people’s lives and health. Previous studies have found that multiple deubiquitinating enzymes are involved in the path...

    Authors: Qingsong Wu, Yuanyuan Qiu, Jinhui Guo, Zibo Yuan, Yingnan Yang, Qingwei Zhu, Zhe Zhang, Junwei Guo, Yanfang Wu, Junyu Zhang, Dongsheng Huang, Kangsheng Tu and Xiaoge Hu
    Citation: Biology Direct 2024 19:13
    Content type: Research Published on:

  47. To create a dual-acting vaccine that can fight against tuberculosis, we combined antigenic arabino-mannan analogues with the Ag85B protein. To start the process, we studied the impact of modifying different pa...

    Authors: Roberta Bernardini, Sara Tengattini, Zhihao Li, Luciano Piubelli, Teodora Bavaro, Anamaria Bianca Modolea, Maurizio Mattei, Paola Conti, Stefano Marini, Yongmin Zhang, Loredano Pollegioni, Caterina Temporini and Marco Terreni
    Citation: Biology Direct 2024 19:11
    Content type: Research Published on:

  48. Neuropathic pain is chronic pain and has few effective control strategies. Studies have demonstrated that microRNAs have functions in neuropathic pain. However, no study has been conducted to demonstrate the r...

    Authors: Yuqi Liu, Lijuan Wang, Chengcheng Zhou, Yuan Yuan, Bin Fang, Kaimei Lu, Fangxia Xu, Lianhua Chen and Lina Huang
    Citation: Biology Direct 2024 19:10
    Content type: Research Published on:

  50. Gerontology research on anti-aging interventions with drugs could be an answer to age-related diseases, aiming at closing the gap between lifespan and healthspan. Here, we present two methods for assaying chro...

    Authors: Mohammad Alfatah, Yizhong Zhang, Arshia Naaz, Trishia Yi Ning Cheng and Frank Eisenhaber
    Citation: Biology Direct 2024 19:8
    Content type: Research Published on:
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