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  1. Antipsychotic drugs are the mainstay of treatment for schizophrenia and provide adjunct therapies for other prevalent psychiatric conditions, including bipolar disorder and major depressive disorder. However, ...

    Authors: Rachel E. Hardy, Injae Chung, Yizhou Yu, Samantha H. Y. Loh, Nobuhiro Morone, Clement Soleilhavoup, Marco Travaglio, Riccardo Serreli, Lia Panman, Kelvin Cain, Judy Hirst, Luis M. Martins, Marion MacFarlane and Kenneth R. Pryde
    Citation: Biology Direct 2023 18:43
    Content type: Research Published on:

  2. Volumetric Muscle Loss (VML), resulting from severe trauma or surgical ablation, is a pathological condition preventing myofibers regeneration, since skeletal muscle owns the remarkable ability to restore tiss...

    Authors: Francesca De Paolis, Stefano Testa, Gabriele Guarnaccia, Alessio Reggio, Ersilia Fornetti, Felice Cicciarelli, Rebecca Deodati, Sergio Bernardini, Daniele Peluso, Jacopo Baldi, Roberto Biagini, Flavia Cobianchi Bellisari, Antonio Izzo, Ferruccio Sgalambro, Francesco Arrigoni, Francesco Rizzo…
    Citation: Biology Direct 2023 18:42
    Content type: Research Published on:

  3. Duchenne muscular dystrophy (DMD) is a severe form of muscular dystrophy caused by mutations in the dystrophin gene. We characterized which isoforms of dystrophin were expressed by human induced pluripotent st...

    Authors: Salwa Soussi, Lesia Savchenko, Davide Rovina, Jason S. Iacovoni, Andrea Gottinger, Maxime Vialettes, Josè-Manuel Pioner, Andrea Farini, Sara Mallia, Martina Rabino, Giulio Pompilio, Angelo Parini, Olivier Lairez, Aoife Gowran and Nathalie Pizzinat
    Citation: Biology Direct 2023 18:41
    Content type: Research Published on:

    The Correction to this article has been published in Biology Direct 2023 18:62

  4. Natural ageing of organisms and corresponding age-related diseases result mainly from stem cell ageing and “inflammaging”. Mesenchymal stem cells (MSCs) exhibit very high immune-regulating capacity and are pro...

    Authors: Xue Yang, Ying Wang, Valentina Rovella, Eleonora Candi, Wei Jia, Francesca Bernassola, Pierluigi Bove, Mauro Piacentini, Manuel Scimeca, Giuseppe Sica, Giuseppe Tisone, Alessandro Mauriello, Lixin Wei, Gerry Melino and Yufang Shi
    Citation: Biology Direct 2023 18:40
    Content type: Review Published on:

  5. Previously, we identified an oncogenic splicing variant of DOCK5 in head and neck squamous cell carcinoma (HNSCC); however, the mechanism for the generation of this specific DOCK5 variant remains unknown. This...

    Authors: Chao Liu, Guo Li, Siyuan Zheng, Li She, Shanhong Lu, Yunyun Wang, Donghai Huang, Xin Zhang, Lunquan Sun, Yong Liu and Yuanzheng Qiu
    Citation: Biology Direct 2023 18:39
    Content type: Research Published on:

  6. Prostate cancer remains one of the deadliest neoplasms in developed countries. Identification of new molecular markers that predict the onset and progression of the disease could improve its clinical managemen...

    Authors: Matthieu Le Hars, Luis Jaime Castro-Vega, Fatemeh Rajabi, David Tabatadze, Martha Romero, Marina Pinskaya and Irina Groisman
    Citation: Biology Direct 2023 18:38
    Content type: Comment Published on:

  7. Intervertebral disc degeneration (IDD) naturally occurs during the aging process. Its occurrence is closely related to chronic inflammation; however, the causal relationship between them is controversial. This...

    Authors: Xingguo Li, Jun Zhang, Bing Wang, Chao Chen, Enyu Zhang, Zhengpin Lv, Qicong He, Yaoquan Hu, Xuenan Wang and Fan Zhang
    Citation: Biology Direct 2023 18:37
    Content type: Research Published on:

  8. LncRNA PSMA3-AS1 functions as an oncogene in several cancers, including ovarian cancer, lung cancer, and colorectal cancer. However, its role in gastric cancer (GC) progression remains unclear. In this study, ...

    Authors: Liang Kan, Meiqi Yang and Huijing Zhang
    Citation: Biology Direct 2023 18:36
    Content type: Research Published on:

  9. Bicuspid aortic valve (BAV) is the most prevalent congenital valvular heart defect, and around 50% of severe isolated calcific aortic valve disease (CAVD) cases are associated with BAV. Although previous studi...

    Authors: Tao Lyu, Yang Liu, Binglin Li, Ran Xu, Jianghong Guo and Dan Zhu
    Citation: Biology Direct 2023 18:35
    Content type: Research Published on:

  10. Tooth development, as one of the major mineralized tissues in the body, require fine-tuning of mineralization micro-environment. The interaction between dental epithelium and mesenchyme plays a decisive role i...

    Authors: MengDan Zhang, Junming Zheng, Siyuan Wu, Hailing Chen and Lusai Xiang
    Citation: Biology Direct 2023 18:34
    Content type: Research Published on:

  12. Adipose tissue, an organ critical for systemic energy homeostasis, is influenced by type 2 immunity in its development and function. The type 2 cytokine interleukin (IL)-4 induces the proliferation of bipotent...

    Authors: Choijamts Munkhzul, Ji-Min Lee, Boseon Kim, Thi Thanh My Nguyen, Rehna Paula Ginting, Dahee Jeong, Young-Kook Kim, Min-Woo Lee and Mihye Lee
    Citation: Biology Direct 2023 18:32
    Content type: Research Published on:

  13. Male factors-caused decline in total fertility has raised significant concern worldwide. LncRNAs have been identified to play various roles in biological systems, including spermatogenesis. This study aimed to...

    Authors: Cong Zhang, Dongxin Lu, Tong Niu, Zhongyi Sun, Yandi Wang, Xiao Han, Bohui Xiong, Wei Shen, Qingyuan Sun, Yong Zhao, Weidong Zhang and Yanni Feng
    Citation: Biology Direct 2023 18:31
    Content type: Research Published on:

  14. Two-dimensional ultrathin Ti3C2 nanosheets are increasingly being used in biomedical applications owing to their special physicochemical properties. But, the biological effects of its exposure on the reproductive...

    Authors: Yang Wei, Ruilin Bao, Le Hu, Yanqing Geng, Xuemei Chen, Yixian Wen, Yingxiong Wang, Mao Qin, Yue Zhang and Xueqing Liu
    Citation: Biology Direct 2023 18:30
    Content type: Research Published on:

  15. Intermittent hypoxia is the best predictor of developing cognitive decline and Alzheimer’s disease progression in patients with obstructive sleep apnea. The nucleotide-binding oligomerization domain-like recep...

    Authors: Yaodan Zhang, Yuyang Miao, Xiangyang Xiong, Jin Tan, Zhaoli Han, Fanglian Chen, Ping Lei and Qiang Zhang
    Citation: Biology Direct 2023 18:29
    Content type: Research Published on:

  16. The predominant cancer-related deaths worldwide are caused by lung cancer, particularly non-small cell lung cancer (NSCLC), despite the fact that numerous therapeutic initiatives have been devised to improve t...

    Authors: Hanqing Zhao, Yanbo Wang, Yaomei He, Peng Zhang, Cheng Zeng, Tongxuan Du, Qiushuo Shen and Song Zhao
    Citation: Biology Direct 2023 18:28
    Content type: Research Published on:

  17. Long non-coding RNAs (lncRNAs) play important roles in the progression of glioma. Here, we examined the potential functions of a lncRNA, LINC01003, in glioma and characterized the underlying molecular mechanis...

    Authors: Xiaolong Zhu, Xingwei Wu, Hui Yang, Qiancheng Xu, Mengying Zhang, Xiaocen Liu and Kun Lv
    Citation: Biology Direct 2023 18:27
    Content type: Research Published on:

  18. The human genome contains nearly 20.000 protein-coding genes, but there are still more than 6,000 proteins poorly characterized. Among them, ZNF330/NOA36 stand out because it is a highly evolutionarily conserv...

    Authors: Alejandra Sanchez-Briñas, Carmen Duran-Ruiz, Antonio Astola, Marta Marina Arroyo, Fátima G. Raposo, Antonio Valle and Jorge Bolivar
    Citation: Biology Direct 2023 18:26
    Content type: Research Published on:

  19. Increasing evidences have shown that long non-coding RNAs (lncRNAs) display crucial regulatory roles in the occurrence and development of numerous diseases. However, the function and underlying mechanisms of l...

    Authors: Yanlin Cao, Jianjun Li, Sujun Qiu, Songjia Ni and Yang Duan
    Citation: Biology Direct 2023 18:25
    Content type: Research Published on:

  20. Out-of-hospital cardiac arrest (OHCA) is one of the most dramatic events in pediatric age and, despite advanced neurointensive care, the survival rate remains low. Currently, no effective treatments can restor...

    Authors: Antonietta Curatola, Benedetta Graglia, Giuseppe Granata, Giorgio Conti, Lavinia Capossela, Luigi Manni, Serena Ferretti, Daniela Di Giuda, Domenico Marco Romeo, Maria Lucia Calcagni, Marzia Soligo, Enrico Castelli, Marco Piastra, Flavio Mantelli, Giacomo Della Marca, Susanna Staccioli…
    Citation: Biology Direct 2023 18:24
    Content type: Research Published on:

  21. Hypertriglyceridemia (HTG) is one of the common causes of acute pancreatitis (AP). Hyperlipidemic acute pancreatitis (HTG-AP) is associated with higher mortality owing to its tendency for greater severity and ...

    Authors: Biwei Wei, Zhou Su, Huiying Yang, Yong Feng, Chunmei Meng and Zhihai Liang
    Citation: Biology Direct 2023 18:23
    Content type: Research Published on:

  22. Synapse diversity has been described from different perspectives, ranging from the specific neurotransmitters released, to their diverse biophysical properties and proteome profiles. However, synapse diversity...

    Authors: Amparo Roig Adam, José A. Martínez-López, Sophie J. F. van der Spek, Patrick F. Sullivan, August B. Smit, Matthijs Verhage and Jens Hjerling-Leffler
    Citation: Biology Direct 2023 18:22
    Content type: Research Published on:

  23. Rhynchophylline (RHY) is an alkaloid component of Uncaria, which are plants extensively used in traditional Asian medicines. Uncaria treatments increase sleep time and quality in humans, and RHY induces sleep ...

    Authors: Maria Neus Ballester Roig, Tanya Leduc, Julien Dufort-Gervais, Yousra Maghmoul, Olivier Tastet and Valérie Mongrain
    Citation: Biology Direct 2023 18:21
    Content type: Research Published on:

  24. The eukaryotic membrane vesicles contain specific sets of proteins that determine vesicle function and shuttle with specific destination. Giardia lamblia contains unknown cytosolic vesicles that are related to th...

    Authors: Jui-Hsuan Wu, Jen-Chi Lee, Chun-Che Ho, Pei-Wei Chiu and Chin-Hung Sun
    Citation: Biology Direct 2023 18:20
    Content type: Research Published on:

  25. Colorectal cancer (CRC) is one of the most common malignant tumors of the digestive system, ranking third for morbidity and mortality worldwide. At present, no effective control method is available for this ca...

    Authors: Tian-yue Liu, Chen-chen Hu, Chen-ying Han, Si-yi Mao, Wen-xin Zhang, Yi-ming Xu, Yuan-jie Sun, Dong-bo Jiang, Xi-yang Zhang, Jia-xing Zhang, Jing Wang, Xu-peng Qiao, Jing-yu Pan, Shu-ya Yang and Kun Yang
    Citation: Biology Direct 2023 18:19
    Content type: Research Published on:

  26. TM4SF1, a member of the transmembrane 4 superfamily, is crucial for both healthy and malignant human tissues. The significant function of TM4SF1 in the incidence and progression of cancer has been widely recog...

    Authors: Si-bo Yang, Zi-han Zhou, Jin Lei, Xiao-wen Li, Qian Chen, Bo Li, Ye-wei Zhang, Yu-zhen Ge and Shi Zuo
    Citation: Biology Direct 2023 18:18
    Content type: Research Published on:

  27. Malignant mesothelioma (MM) is a rare tumor with a dismal prognosis. The low efficacy of current treatment options highlights the urge to identify more effective therapies aimed at improving MM patients’ survi...

    Authors: Monica Benvenuto, Valentina Angiolini, Chiara Focaccetti, Daniela Nardozi, Camilla Palumbo, Raffaele Carrano, Alessandra Rufini, Riccardo Bei, Martino Tony Miele, Patrizia Mancini, Giovanni Barillari, Mara Cirone, Elisabetta Ferretti, Grazia Raffaella Tundo, Luciano Mutti, Laura Masuelli…
    Citation: Biology Direct 2023 18:17
    Content type: Research Published on:

  28. With the rapidly increasing morbidity and mortality, lung cancer has been considered one of the serious malignant tumors, affecting millions of patients globally. Currently, the pathogenesis of lung cancer rem...

    Authors: Lei Cao, Hongsheng Liu, Cheng Huang, Chao Guo, Luo Zhao, Chao Gao, Yuan Xu, Guige Wang, Naixin Liang and Shanqing Li
    Citation: Biology Direct 2023 18:16
    Content type: Research Published on:

  29. Accumulating studies have demonstrated that the Warburg effect plays a central role in the occurrence and development of hepatocellular carcinoma (HCC), albeit the role of non-coding RNA (lncRNA) in its associ...

    Authors: Chuanjiang Liu, Kequan Xu, Jiayin Liu, Chao He, Pan Liu, Qiang Fu, Hongwei Zhang and Tao Qin
    Citation: Biology Direct 2023 18:15
    Content type: Research Published on:

  31. Authors: Melina Muñoz-Bernart, Nicolás Budnik, Araceli Castro, Malena Manzi, María Eugenia Monge, Julieta Pioli, Sebastián Defranchi, Gustavo Parrilla, Juan Pablo Santilli, Kevin Davies, Joaquín M. Espinosa, Ken Kobayashi, Carlos Vigliano and Carolina Perez-Castro
    Citation: Biology Direct 2023 18:13
    Content type: Correction Published on:

    The original article was published in Biology Direct 2023 18:8

  32. Viruses rely on hosts for life and reproduction, cause a variety of symptoms from common cold to AIDS to COVID-19 and provoke public health threats claiming millions of lives around the globe. RNA editing, as ...

    Authors: Tongtong Zhu, Guangyi Niu, Yuansheng Zhang, Ming Chen, Chuan-Yun Li, Lili Hao and Zhang Zhang
    Citation: Biology Direct 2023 18:12
    Content type: Review Published on:

  33. Recent development of human three-dimensional organoid cultures has opened new doors and opportunities ranging from modelling human development in vitro to personalised cancer therapies. These new in vitro sys...

    Authors: Artem Smirnov, Gerry Melino and Eleonora Candi
    Citation: Biology Direct 2023 18:11
    Content type: Review Published on:

  34. In tumor therapy anti-angiogenic approaches have the potential to increase the efficacy of a wide variety of subsequently or co-administered agents, possibly by improving or normalizing the defective tumor vas...

    Authors: David Ascheid, Magdalena Baumann, Caroline Funke, Julia Volz, Jürgen Pinnecker, Mike Friedrich, Marie Höhn, Rajender Nandigama, Süleyman Ergün, Bernhard Nieswandt, Katrin G. Heinze and Erik Henke
    Citation: Biology Direct 2023 18:10
    Content type: Research Published on:

  35. Long-term consumption of an excessive fat and sucrose diet (Western diet, WD) has been considered a risk factor for metabolic syndrome (MS) and cardiovascular disease. Caveolae and caveolin-1 (CAV-1) proteins ...

    Authors: I.-Fan Liu, Tzu-Chieh Lin, Shu-Chi Wang, Chia-Hung Yen, Chia-Yang Li, Hsuan-Fu Kuo, Chong-Chao Hsieh, Chia-Yuan Chang, Chuang-Rung Chang, Yung-Hsiang Chen, Yu-Ru Liu, Tsung-Ying Lee, Chi-Yuan Huang, Chih-Hsin Hsu, Shing-Jong Lin and Po-Len Liu
    Citation: Biology Direct 2023 18:9
    Content type: Research Published on:

  36. Lung cancer is one of the most frequently diagnosed cancers characterized by high mortality, metastatic potential, and recurrence. Deregulated gene expression of lung cancer, likewise in many other solid tumor...

    Authors: Melina Muñoz-Bernart, Nicolás Budnik, Araceli Castro, Malena Manzi, María Eugenia Monge, Julieta Pioli, Sebastián Defranchi, Gustavo Parrilla, Juan Pablo Santilli, Kevin Davies, Joaquín M. Espinosa, Ken Kobayashi, Carlos Vigliano and Carolina Perez-Castro
    Citation: Biology Direct 2023 18:8
    Content type: Research Published on:

    The Correction to this article has been published in Biology Direct 2023 18:13

  37. Although Escherichia coli (E. coli) is the most studied prokaryote organism in the history of life sciences, many molecular mechanisms and gene functions encoded in its genome remain to be discovered. This work a...

    Authors: Erwin Tantoso, Birgit Eisenhaber, Swati Sinha, Lars Juhl Jensen and Frank Eisenhaber
    Citation: Biology Direct 2023 18:7
    Content type: Research Published on:

  38. Acute myocardial infarction is a major health problem and is the leading cause of death worldwide. Myocardial apoptosis induced by myocardial infarction injury is involved in the pathophysiology of heart failu...

    Authors: Tingting Wang, Tao Li, Xiaolin Niu, Lang Hu, Jin Cheng, Dong Guo, He Ren, Ran Zhao, Zhaole Ji, Pengyun Liu, Yan Li and Yanjie Guo
    Citation: Biology Direct 2023 18:6
    Content type: Research Published on:

  40. Cuproptosis is a new type of copper-induced cell death that is characterized by the aggregation of lipoylated tricarboxylic acid (TCA) cycle proteins. However, its role in hepatocellular carcinoma (HCC) remain...

    Authors: Yuqiao Chen, Lu Tang, Wentao Huang, Fakolade Hannah Abisola, Youyu Zhang, Gewen Zhang and Lei Yao
    Citation: Biology Direct 2023 18:4
    Content type: Research Published on:

  41. Long intergenic non-coding RNA 326 (LINC00326) modulates hepatocarcinogenic lipid metabolism. However, the ability of LINC00326 to modulate the highly aggressive non-small cell lung carcinoma (NSCLC) is unknow...

    Authors: Yingqian Zhang, Jiao Yuan, Mengfei Guo, Run Xiang, Tianpeng Xie, Xiang Zhuang, Wei Dai, Qiang Li and Qi Lai
    Citation: Biology Direct 2023 18:3
    Content type: Research Published on:

  42. Radiation-induced pulmonary fibrosis (RIPF) is a major side effect experienced for patients with thoracic cancers after radiotherapy. RIPF is poor prognosis and limited therapeutic options available in clinic. La...

    Authors: Zhao Ju, Huiji Pan, Can Qu, Liang Xiao, Meiling Zhou, Yin Wang, Jinhua Luo, Liangfang Shen, Pingkun Zhou and Ruixue Huang
    Citation: Biology Direct 2023 18:2
    Content type: Research Published on:

  43. Pancreatic cancer (PC) is a highly lethal malignancy that requires effective novel therapies. M2 macrophages are abundant in the PC microenvironment and promote cancer progression. Exosomes are emerging mediat...

    Authors: Ke Zhang, Yu-Jie Li, Lin-Jia Peng, Hui-Feng Gao, Lu-Ming Liu and Hao Chen
    Citation: Biology Direct 2023 18:1
    Content type: Research Published on:

  44. Metastasis constitutes one of the major causes of tumor-related death in gastric cancer (GC), and understanding key events in the initiation of this phenotypic switch may provide therapeutic opportunities. Lon...

    Authors: Yunxin Lu, Qi Meng, Long Bai, Ruobing Wang, Yong Sun, Jiaqi Li, Jun Fan and Tian Tian
    Citation: Biology Direct 2022 17:41
    Content type: Research Published on:

  45. ACTN4 is an actin-binding protein involved in many cellular processes, including cancer development. High ACTN4 expression is often associated with a poor prognosis. However, it has been identified as a positi...

    Authors: Daria Kriger, Ksenia Novitskaya, Giomar Vasileva, Ekaterina Lomert, Nikolai D. Aksenov, Nikolai A. Barlev and Dmitri Tentler
    Citation: Biology Direct 2022 17:40
    Content type: Research Published on:

  46. Originally discovered by Nielsen in 1991, peptide nucleic acids and other artificial genetic polymers have gained a lot of interest from the scientific community. Due to their unique biophysical features these...

    Authors: Gleb S. Ivanov, Vyacheslav G. Tribulovich, Nikolay B. Pestov, Temitope I. David, Abdul-Saleem Amoah, Tatyana V. Korneenko and Nikolai A. Barlev
    Citation: Biology Direct 2022 17:39
    Content type: Review Published on:

  47. Nuclear organisation and architecture are essential for the maintenance of genomic integrity as well as for the epigenetic regulations and gene expression. Disruption of lamin B1, major structural and function...

    Authors: Emanuele Panatta, Alessio Butera, Ivana Celardo, Marcel Leist, Gerry Melino and Ivano Amelio
    Citation: Biology Direct 2022 17:38
    Content type: Research Published on:

  48. In mouse liver hepatocytes, nearly half of the surface area of every mitochondrion is covered by wrappER, a wrapping-type of ER that is rich in fatty acids and synthesizes lipoproteins (VLDL) (Anastasia et al....

    Authors: Nicolò Ilacqua, Irene Anastasia, Danylo Aloshyn, Rana Ghandehari-Alavijeh, Emily Ann Peluso, Madelaine C. Brearley-Sholto, Leonardo V. Pellegrini, Andrea Raimondi, Thomas Q. de Aguiar Vallim and Luca Pellegrini
    Citation: Biology Direct 2022 17:37
    Content type: Research Published on:

  49. The major histocompatibility complex (MHC) and the killer cell immunoglobulin-like receptors (KIR) are key regulators of immune responses. The cynomolgus macaque, an Old World monkey species, can be applied as...

    Authors: Qingxiu Hu, Xiaoqi Huang, Yabin Jin, Rui Zhang, Aimin Zhao, Yiping Wang, Chenyun Zhou, Weixin Liu, Xunwei Liu, Chunhua Li, Guangyi Fan, Min Zhuo, Xiaoning Wang, Fei Ling and Wei Luo
    Citation: Biology Direct 2022 17:36
    Content type: Research Published on:

  50. Acute lung injury (ALI) is a major cause of respiratory failure in critically ill patients that results in significant morbidity and mortality. Recent studies indicate that cell-based therapies may be benefici...

    Authors: Lijuan Xu, Yunlou Zhu, Congye Li, Qixing Wang, Lijie Ma, Junjie Wang and Shouqin Zhang
    Citation: Biology Direct 2022 17:35
    Content type: Research Published on:
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  • Citation Impact 2023
    Journal Impact Factor: 5.7
    5-year Journal Impact Factor: 4.5
    Source Normalized Impact per Paper (SNIP): 1.060
    SCImago Journal Rank (SJR): 1.161

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    Submission to first editorial decision (median days): 3
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Biology Direct

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