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Fig. 3 | Biology Direct

Fig. 3

From: MIR194-2HG, a miRNA host gene activated by HNF4A, inhibits gastric cancer by regulating microRNA biogenesis

Fig. 3

MIR194-2HG was involved in miR-194/192 microRNA biogenesis. (A) The subcellular location of MIR194-2HG transcripts in GC cell lines. (B) The expression correlation analysis between MIR194-2HG and per microRNA was performed in GC. (C) MIR194-2HG was highly co-expressed with miR-194 and miR-192 in GC tissues. (D, E) Northern blotting assays showed that MIR194-2HG knockdown decreased the expression level of mature and precursor forms of miR-194 and miR-192. (F-I) Quantitative RT-PCR assay showed that MIR194-2HG knockdown significantly downregulated the expression level of pre-miR-192, miR-192, pre-miR-194-2, and miR-194 in GC cell lines

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Biology Direct

ISSN: 1745-6150

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