Skip to main content
Fig. 8 | Biology Direct

Fig. 8

From: MIR194-2HG, a miRNA host gene activated by HNF4A, inhibits gastric cancer by regulating microRNA biogenesis

Fig. 8

Hypothetical working model of MIR194-2HG in GC. Briefly, MIR194-2HG expression is clinically associated with favorable prognosis and plays tumor suppressive roles in GC. Mechanically, MIR194-2HG expression was transcriptionally induced by the hepatocyte nuclear factor HNF4A. Meanwhile, MIR194-2HG positively regulates the expression of its derived miR-194 and miR-192. The oncogene BTF3L4 has been confirmed to be a common target gene of miR-192 and miR-194. MIR194-2HG knockdown promotes GC progression by maintaining BTF3L4 overexpression through regulating microRNA biogenesis if miR-194/192

Back to article page

Biology Direct

ISSN: 1745-6150

Contact us