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Fig. 2 | Biology Direct

Fig. 2

From: ALKBH5 activates CEP55 transcription through m6A demethylation in FOXP2 mRNA and expedites cell cycle entry and EMT in ovarian cancer

Fig. 2

CEP55 inhibits the malignant behavior of OC cells. A, CEP55 expression in A2780 and SKOV3 cells infected with lentiviral vectors harboring CEP55 knockdown assessed using RT-qPCR. B, The number of A2780 and SKOV3 cells-formed colonies was assessed using colony formation assay. C, The proliferation of A2780 and SKOV3 cells was assessed using an EdU assay. D, The expression of proliferation-related genes KI67 and PCNA in A2780 and SKOV3 cells with knockdown of CEP55 was assessed using RT-qPCR. E, Percentage of apoptosis in A2780 and SKOV3 cells with knockdown of CEP55 detected by TUNEL assay. Statistical significance was assessed using ANOVA. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001. All cell experiments were repeated three times

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