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Fig. 6 | Biology Direct

Fig. 6

From: ALKBH5 activates CEP55 transcription through m6A demethylation in FOXP2 mRNA and expedites cell cycle entry and EMT in ovarian cancer

Fig. 6

FOXP2-mediated transcriptional repression of CEP55 impedes OC cell growth and metastasis in vivo. A, Representative images of abdominal tumors formed by SKOV3 cells in mice. B, Total weight of tumor nodules in the abdominal cavity of mice. C, HE staining analysis of metastatic nodules in mouse lung tissue. D, EMT- and cell cycle-related protein expression in abdominal tumors was assessed using western blot analysis. E, The mRNA expression of FOXP2 and CEP55 in abdominal tumors was evaluated using RT-qPCR. Statistical significance was assessed using ANOVA (n = 6). *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001

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Biology Direct

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