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  1. Biosynthesis of 17β-estradiol (E2) is a crucial ovarian function in mammals, which is essential for follicular development and pregnancy outcome. Exploring the epigenetic regulation of E2 synthesis is benefici...

    Authors: Zhennan Guo, Qiang Zeng, Qiqi Li, Baosen Shan, Yangan Huo, Xiaoli Shi, Qifa Li and Xing Du
    Citation: Biology Direct 2024 19:107
    Content type: Research Published on:

  3. Centrosomal protein of 55 kDa (CEP55) overexpression has been linked to tumor stage, aggressiveness of the tumor, poor prognosis, and metastasis. This study aims to elucidate the action of CEP55 in ovarian can...

    Authors: Junhui Yu, Xing Chen, Xiaoxiao Ding, Kang Lin, Tianxin Zhang and Kai Wang
    Citation: Biology Direct 2024 19:105
    Content type: Research Published on:

  4. The growing body of evidence suggests that RNA-binding proteins (RBPs) have an important function in cancer biology. This research characterizes the expression status of fragile X-related protein 1 (FXR1) in e...

    Authors: Faiz Ali Khan, Dalia Fouad, Farid S. Ataya, Na Fang, Jingcheng Dong and Shaoping Ji
    Citation: Biology Direct 2024 19:104
    Content type: Research Published on:

  5. Accurately identifying effective biomarkers and translating them into clinical practice have significant implications for improving clinical outcomes in hepatocellular carcinoma (HCC). In this study, our objec...

    Authors: Xiaokai Yan, Yao Qi, Xinyue Yao, Lulu Yin, Hao Wang, Ji Fu, Guo Wan, Yanqun Gao, Nanjing Zhou, Xinxin Ye, Xiao Liu and Xing Chen
    Citation: Biology Direct 2024 19:103
    Content type: Research Published on:

  6. The role of the RING finger protein superfamily in carcinogenesis has been widely studied, but one member of this family, RNF19A, has not yet been thoroughly explored in bladder cancer (BCa).

    Authors: Hao Deng, Guanghai Ji, Jun Ma, Jun Cai, Shaoping Cheng and Fan Cheng
    Citation: Biology Direct 2024 19:102
    Content type: Research Published on:

  7. Identifying therapeutic inhibitors of crucial enzymes involved in the peptidoglycan biosynthesis pathway is pivotal for developing new treatments against multidrug-resistant Enterococcus faecalis V583. MurM, an e...

    Authors: Km.Rakhi, Monika Jain, Amit Kumar Singh, Mohd Sajid Ali, Hamad A. Al-Lohedan and Jayaraman Muthukumaran
    Citation: Biology Direct 2024 19:101
    Content type: Research Article Published on:

  8. Alzheimer’s disease (AD) is a complex neurodegenerative disorder significantly impairing cognitive faculties, memory, and physical abilities. To characterize the modulation of the gut microbiota in an in vivo ...

    Authors: Francesco Favero, Angela Re, Mohammed Salim Dason, Teresa Gravina, Mara Gagliardi, Marta Mellai, Marco Corazzari and Davide Corà
    Citation: Biology Direct 2024 19:100
    Content type: Research Published on:

  9. This study aimed to elucidate the role and underlying mechanisms of Peroxisome proliferator-activated receptor gamma (PPARγ) and its m6A methylation in renal ischemia-reperfusion (I/R) injury and ferroptosis o...

    Authors: Wei Liu, Ziqing Xiong, Tianmei Fu, Juan Yang, Juan Zou, Yize Wu, Linju Kuang, Qian Wang, Song Li and Aiping Le
    Citation: Biology Direct 2024 19:99
    Content type: Research Published on:

  10. Spiroplasma eriocheiris has been proved to be a pathogen causing tremor disease of Eriocheir sinensis, it is also infectious to other aquatic crustaceans, resulting in a serious threat on the sustainable developm...

    Authors: Rong Li, Xiaohui Cao, Jiaxin Chen, Tingting He, Yan Zhang, Wen Wang, Yaqi Wang, Yifei Wang, Yanyan Qiu, Mengji Xie, Kailin Shi, Yuhua Xu, Siyuan Zhang and Peng Liu
    Citation: Biology Direct 2024 19:98
    Content type: Research Published on:

  11. Disulfidptosis refers to cell death caused by the accumulation and bonding of disulfide in the cytoskeleton protein of SLC7A11-high level cells under glucose deprivation. However, the role of disulfidptosis-re...

    Authors: Zhen Kang, Zheng-Hua Wan, Rui-Cheng Gao, Dong-Ning Chen, Qing-Shui Zheng, Xue-Yi Xue, Ning Xu and Yong Wei
    Citation: Biology Direct 2024 19:97
    Content type: Research Published on:

  12. Vaginal infections caused by multidrug-resistant pathogens such as Candida albicans and Gardnerella spp. represent a significant health challenge. Current treatments often fail because of resistance and toxicity....

    Authors: Ling Fang, Tiancheng Yang, Haojue Wang and Jun Cao
    Citation: Biology Direct 2024 19:96
    Content type: Research Published on:

  14. Lung cancer is one of the most frequent cancers and the leading cause of cancer-related deaths worldwide with poor prognosis. A disintegrin and metalloproteinase with thrombospondin motifs 4 (ADAMTS4) is cruci...

    Authors: Wei Zhai, Wensheng Yang, Jing Ge, Xuelian Xiao, Kang Wu, Kelin She, Yu Zhou, Yi Kong, Lin Wu, Shiya Luo and Xingxiang Pu
    Citation: Biology Direct 2024 19:94
    Content type: Research Published on:

  15. The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is reliably one of the largest pandemics the world has suffered in recent years. In the search for non-biological antivirals, special emphasis w...

    Authors: Michela Murdocca, Osvaldo Andrade Santos-Filho, Claudia De Masi, Edivaldo dos Santos Rodrigues, Claudia Valeria Campos de Souza, Riccardo De Santis, Donatella Amatore, Andrea Latini, Rossella Schipani, Lino di Rienzo Businco, Bruno Brandimarte, Giorgia Grilli, Tien L Huang, Annie S Mayence, Florigio Lista, Andrea Duranti…
    Citation: Biology Direct 2024 19:93
    Content type: Research Published on:

  16. Ischemia/reperfusion (I/R) injury is a severe brain disorder with currently limited effective treatments. This study aims to explore the role of N6-methyladenosine (m6A) modification and associated regulatory ...

    Authors: Zhengtao Yu, Ying Xia, Jiameng Li, Junwen Jiang, You Li, Youjun Li and Liu Wang
    Citation: Biology Direct 2024 19:92
    Content type: Research Published on:

  17. The complex network governing self-renewal in epidermal stem cells (EPSCs) is only partially defined. FOXM1 is one of the main players in this network, but the upstream signals regulating its activity remain t...

    Authors: Maria Pia Polito, Alessio Romaldini, Lorenzo Tagliazucchi, Grazia Marini, Federica Radice, Gaia Andrea Gozza, Giulia Bergamini, Maria Paola Costi and Elena Enzo
    Citation: Biology Direct 2024 19:91
    Content type: Research Published on:

  18. miR-210 is one of the most evolutionarily conserved microRNAs. It is known to be involved in several physiological and pathological processes, including response to hypoxia, angiogenesis, cardiovascular diseas...

    Authors: Davide Colaianni, Federico Virga, Annamaria Tisi, Chiara Stefanelli, Germana Zaccagnini, Paola Cusumano, Gabriele Sales, Mihai Bogdan Preda, Fabio Martelli, Daniela Taverna, Massimiliano Mazzone, Cristiano Bertolucci, Rita Maccarone and Cristiano De Pittà
    Citation: Biology Direct 2024 19:90
    Content type: Research Published on:

  19. Endometrial cancer (EC) presents significant clinical challenges due to its heterogeneity and complex pathophysiology. SAMHD1, known for its role as a deoxynucleotide triphosphate triphosphohydrolase, has been...

    Authors: Ping Qiang, Ying Chen, Yang Shao, Qicheng Deng, Songyuan Xu and Weipei Zhu
    Citation: Biology Direct 2024 19:89
    Content type: Research Published on:

  20. Motile Sperm Domain-Containing Protein 1 (MOSPD1) has been implicated in breast cancer (BC) pathophysiology, but its exact role remains unclear. This study aimed to assess MOSPD1 expression levels in BC versus...

    Authors: Yiling Jiang, Hailong Li, Sixuan Wu, Baohong Jiang, Lijun Zeng, Yuanbin Tang, Lunqi Luo, Lianjie Ouyang, Wei Du and Yuehua Li
    Citation: Biology Direct 2024 19:88
    Content type: Research Published on:

  21. Plants have an amazing ability to adapt to their environment, and this extends beyond biochemical responses and includes developmental changes that help them better exploit resources and survive. The plasticit...

    Authors: Kavya Yalamanchili, Joop E. M. Vermeer, Ben Scheres and Viola Willemsen
    Citation: Biology Direct 2024 19:87
    Content type: Review Published on:

  22. The immune response gene 1 (IRG1) and its metabolite itaconate are implicated in modulating inflammation and oxidative stress, with potential relevance to sepsis-induced myocardial dysfunction (SIMD). This stu...

    Authors: Song Shen, Jianhui Li, Zhonghai Wei, Yihai Liu, Lina Kang, Rong Gu, Xuan Sun, Biao Xu and QiaoLing Li
    Citation: Biology Direct 2024 19:86
    Content type: Research Published on:

  23. Skin healing is a complex and dynamic physiological process that follows mechanical alteration of the skin barrier. Under normal conditions, this complex process can be divided into at least three continuous a...

    Authors: S. Gandolfi, A. Sanouj, B. Chaput, A. Coste, B. Sallerin and A. Varin
    Citation: Biology Direct 2024 19:85
    Content type: Review Published on:

  25. Breast cancer (BC) is a great clinical challenge because of its aggressiveness and poor prognosis. Zinc Finger Protein 64 (ZFP64), as a transcriptional factor, is responsible for the development and progressio...

    Authors: Jiayi Sun, Jinquan Liu, Yudong Hou, Jianheng Bao, Teng Wang, Longbi Liu, Yidan Zhang, Rui Zhong, Zhenxuan Sun, Yan Ye and Jintao Liu
    Citation: Biology Direct 2024 19:83
    Content type: Research Published on:

  27. Limited supply of certain nutrients and deregulation of nucleus pulposus (NP) plays a key role in the pathogenesis of intervertebral disc degeneration (IVDD). However, whether nutrient deprivation-induced cell...

    Authors: Shaobo Wu, Jin Wang, Minglin Wang, Kaisheng Zhou, Dageng Huang, Yilei Zhang and Haihong Zhang
    Citation: Biology Direct 2024 19:81
    Content type: Research Published on:

  29. Esophageal squamous cell carcinoma (ESCC) is often diagnosed at advanced stages due to the inherent limitations of current screening methodologies. Central to evaluating tumor invasion and prognostic assessmen...

    Authors: Han Zhang, Xia Zhang, Zhenyu Huang and Hao Zhang
    Citation: Biology Direct 2024 19:79
    Content type: Research Published on:

  30. Choriocarcinoma is a malignant cancer that belongs to gestational trophoblastic neoplasia (GTN). Herein, serum metabolomic analysis was performed on 29 GTN patients and 30 healthy individuals to characterize t...

    Authors: Xiao-Mei Liu, Zi-Hao Wang, Qian-Xue Wei, Yang Song and Xiao-Xin Ma
    Citation: Biology Direct 2024 19:78
    Content type: Research Published on:

  31. GALNTs (UDP-GalNAc; polypeptide N-acetylgalactosaminyltransferases) initiate mucin-type O-GalNAc glycosylation by adding N-GalNAc to protein serine/threonine residues. Abnormalities in O-GalNAc glycosylation a...

    Authors: Yuanwen Peng, Jun Liu, Lili Sun, Qiuying Zheng, Can Cao, Wenyong Ding, Shufeng Yang, Li Ma and Wenli Zhang
    Citation: Biology Direct 2024 19:77
    Content type: Research Published on:

  32. Moyamoya disease, characterized by basal cerebral artery obstruction, was studied for differential protein expression to elucidate its pathogenesis. Proteomic analysis of cerebrospinal fluid from 10 patients, ...

    Authors: Dong Guo, Yang Dong, Hongbin Li, Hongwei Li and Bo Yang
    Citation: Biology Direct 2024 19:76
    Content type: Research Published on:

  33. Gastrin is a gastrointestinal peptide hormone that plays an important role in the progression of colorectal cancer (CRC). However, the molecular mechanism remains unclear. In this study, we identified gastrin-...

    Authors: Xu Wang, Tianjiao Sun, Jiapeng Fan, Xueliang Zuo and Jiading Mao
    Citation: Biology Direct 2024 19:75
    Content type: Research Published on:

  34. Excavation of key molecules can help identify therapeutic targets and improve the prognosis of pancreatic cancer. This study evaluated the roles of SUMO3 in cell viability, glycolysis, gemcitabine (GEM) sensit...

    Authors: Liming Zhu, Gang Chen, Changjing Huang, Huifeng Gao, Yilin Wang and Yehua Shen
    Citation: Biology Direct 2024 19:74
    Content type: Research Published on:

  35. Hematopoietic stem cells (HSCs) exhibit significant functional and metabolic alterations within the lung cancer microenvironment, contributing to tumor progression and immune evasion by increasing differentiat...

    Authors: Ziqi Guo, Yaping Liu, Xin Li, Yuying Huang, Zuping Zhou and Cheng Yang
    Citation: Biology Direct 2024 19:73
    Content type: Research Published on:

    The Correction to this article has been published in Biology Direct 2024 19:84

  36. TSPAN7 is an important factor in tumor progression. However, the precise function of TSPAN7 and its role in pan-cancer are not clear.

    Authors: Bingnan Lu, Yifan Liu, Yuntao Yao, Dawei Zhu, Xiangmin Zhang, Keqin Dong, Xiao Xu, Donghao Lv, Zihui Zhao, Haoyu Zhang, Xinyue Yang, Wenjia Fu, Runzhi Huang, Jianwei Cao, Jian Chu, Xiuwu Pan…
    Citation: Biology Direct 2024 19:72
    Content type: Research Published on:

  37. Kidney renal clear cell carcinoma (KIRC) represents a significant proportion of renal cell carcinomas and is characterized by high aggressiveness and poor prognosis despite advancements in immunotherapy. Disul...

    Authors: Kangjie Xu, Dongling Li, Kangkang Ji, Yanhua Zhang, Minglei Zhang, Hai Zhou, Xuefeng Hou, Jian Jiang, Zihang Zhang, Hua Dai and Hang Sun
    Citation: Biology Direct 2024 19:71
    Content type: Research Published on:

  38. The recombination landscape and subsequent natural selection have vast consequences forevolution and speciation. However, most of the crossover and recombination hotspots are yet to be discovered. We previousl...

    Authors: Mina Ohadi, Masoud Arabfard, Safoura Khamse, Samira Alizadeh, Sara Vafadar, Hadi Bayat, Nahid Tajeddin, Ali M. A. Maddi, Ahmad Delbari and Hamid R. Khorram Khorshid
    Citation: Biology Direct 2024 19:70
    Content type: Research Published on:

  39. A substantive body of evidence has demonstrated the significant roles of circular RNA (circRNA) in cancer. However, the contribution of dysregulated circRNAs to ovarian cancer (OC) remains elusive. We aim to e...

    Authors: Yu Sun, Xiyi Chen, Yaqian Shi, Fang Teng, Chencheng Dai, Lili Ge, Juan Xu and Xuemei Jia
    Citation: Biology Direct 2024 19:69
    Content type: Research Published on:

  40. Cancer-associated fibroblasts (CAFs) have been reported that can affect cancer cell proliferation, metastasis, ferroptosis, and immune escape. METTL3-mediated N6-methyladenine (m6A) modification is involved in...

    Authors: Hongtao Ren, Mincong Wang, Xiulong Ma, Lei An, Yuyan Guo and Hongbing Ma
    Citation: Biology Direct 2024 19:68
    Content type: Research Published on:

  41. The cell and molecular bases of arbuscular mycorrhizal (AM) symbiosis, a crucial plant-fungal interaction for nutrient acquisition, have been extensively investigated by coupling traditional RNA sequencing tec...

    Authors: Sofía Cristina Somoza, Paola Bonfante and Marco Giovannetti
    Citation: Biology Direct 2024 19:67
    Content type: Review Published on:

  42. Breast cancer is the most common cause of death from cancer in women. Here, we present the case of a 43-year-old woman, who received a diagnosis of claudin-low luminal B breast cancer. The lesion revealed to b...

    Authors: Sara Giovannini, Artem Smirnov, Livia Concetti, Manuel Scimeca, Alessandro Mauriello, Julia Bischof, Valentina Rovella, Gerry Melino, Claudio Oreste Buonomo, Eleonora Candi and Francesca Bernassola
    Citation: Biology Direct 2024 19:66
    Content type: Research Published on:

  43. Disulfidptosis is a newly identified mechanism of cell death triggered by disulfide stress. Thus, gaining a comprehensive understanding of the disulfidptosis signature present in gastric cancer (GC) could grea...

    Authors: Zitao Liu, Liang Sun, Wenjie Zhu, Jinfeng Zhu, Changlei Wu, Xingyu Peng, Huakai Tian, Chao Huang and Zhengming Zhu
    Citation: Biology Direct 2024 19:65
    Content type: Research Published on:

  44. It was a Lucky Strike to be working with Eraldo Antonini on hemoglobin and myoglobin when Jeffries Wyman arrived in Rome in 1961. I found myself connected with a number of creative scientists when the concept ...

    Authors: Maurizio Brunori
    Citation: Biology Direct 2024 19:64
    Content type: Review Published on:

  45. Epidermal stem cells (EPSCs) are essential for maintaining skin homeostasis and ensuring a proper wound healing. During in vitro cultivations, EPSCs give rise to transient amplifying progenitors and differentiate...

    Authors: Maria Pia Polito, Alessio Romaldini, Serena Rinaldo and Elena Enzo
    Citation: Biology Direct 2024 19:63
    Content type: Review Published on:

  46. High glucose levels are key factors and key contributors to several cardiovascular diseases associated with cardiomyocyte injury. Ferroptosis, which was identified in recent years, is a mode of cell death caus...

    Authors: Pengfei Wang, Xiaohua Guo, Hongchao Wang, Lijie Wang, Meifang Ma and Bingyan Guo
    Citation: Biology Direct 2024 19:62
    Content type: Research Published on:

  47. Myofibroblast buildup and prostatic fibrosis play a crucial role in the development of benign prostatic hyperplasia (BPH). Treatments specifically targeting myofibroblasts could be a promising approach for tre...

    Authors: Tiewen Li, Yu Zhang, Zeng Zhou, Lvxin Guan, Yichen Zhang, Zhiyuan Zhou, Wenhao Wang, Xuehao Zhou, Di Cui, Chenyi Jiang and Yuan Ruan
    Citation: Biology Direct 2024 19:61
    Content type: Research Published on:

  48. Retrotransposition is one of the main factors responsible for gene duplication and thus genome evolution. However, the sequences that undergo this process are not only an excellent source of biological diversi...

    Authors: Joanna Kozłowska-Masłoń, Joanna Ciomborowska-Basheer, Magdalena Regina Kubiak and Izabela Makałowska
    Citation: Biology Direct 2024 19:60
    Content type: Research Published on:

  50. Cluster of Differentiation 1 (CD1) proteins are widely expressed throughout jawed vertebrates and present lipid antigens to specific CD1-restricted T lymphocytes. CD1 molecules play an important role in immune...

    Authors: Konstantin V. Gunbin, Gelina S. Kopeina, Boris Zhivotovsky and Alexey V. Zamaraev
    Citation: Biology Direct 2024 19:58
    Content type: Research Published on:
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