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  1. Diabetic nephropathy (DN) is a common diabetes-related complication with unclear underlying pathological mechanisms. Although recent studies have linked glycolysis to various pathological states, its role in D...

    Authors: Chenglong Fan, Guanglin Yang, Cheng Li, Jiwen Cheng, Shaohua Chen and Hua Mi
    Citation: Biology Direct 2025 20:10
    Content type: Research Published on:

  3. Tumor microenvironment (TME) takes an essential part in the bladder cancer progression, which is associated with intercellular cross-talk between stroma cells and cancer. We aimed use bioinformatics tools to a...

    Authors: Fang Fang, Tiange Wu, Mengxue Wang, Wenchao Li, Zonghao You, Ming Chen and Han Guan
    Citation: Biology Direct 2025 20:8
    Content type: Research Published on:

  4. Thioredoxin1 (TRX1) and telomerase are both attractive oncology targets that are tightly implicated in tumor initiation and development. Here, we reported that the 6-dithio-2-deoxyguanosine analog thiotert exh...

    Authors: Qiangan Jing, Yunyi Wu, Yanchun Li, Chaoting Zhou, Junyu Zhang, Jun Xia, Keyi Li, Yuhuan Shen, Hongfeng Yao, Xiangmin Tong, Jing Du, Lushan Yu and Ying Wang
    Citation: Biology Direct 2025 20:7
    Content type: Research Published on:

  5. Pancreatic cancer is a lethal disease with an insidious onset, and little is known about its early molecular events. Here, we found that the sterol regulatory element-binding protein 1 (SREBP1) expression is g...

    Authors: Cancan Zhou, Zhengyuan Feng, Weikun Qian, Zeen Zhu, Ruiqi Cao, Qiqi Wang, Wunai Zhang, Rujuan Liu, Shuai Wu, Jie Hao, Zheng Wang, Qingyong Ma, Zheng Wu and Xuqi Li
    Citation: Biology Direct 2025 20:6
    Content type: Research Published on:

  6. Pancreatic cancer is characterized by a complex tumor microenvironment that hinders effective immunotherapy. Identifying key factors that regulate the immunosuppressive landscape is crucial for improving treat...

    Authors: Qihui Sun, Xiaoqi Zhu, Qi Zou, Yang Chen, Tingting Wen, Tingting Jiang, Xiaojia Li, Fang Wei, Keping Xie and Jia Liu
    Citation: Biology Direct 2025 20:5
    Content type: Research Published on:

  7. Despite the increasing body of evidence that mitochondrial activities implicate in chronic obstructive pulmonary disease (COPD), we are still far from a causal-logical and mechanistic understanding of the mito...

    Authors: Xiaoli Zou, Qiqing Huang, Tutu Kang, Shaoran Shen, Chenxi Cao and Jianqing Wu
    Citation: Biology Direct 2025 20:4
    Content type: Research Published on:

  8. Endothelial cells are integral components of the tumor microenvironment and play a multifaceted role in tumor immunotherapy. Targeting endothelial cells and related signaling pathways can improve the effective...

    Authors: Gujun Cong, Jingjing Shao, Feng Xiao, Haixia Zhu and Peipei Kang
    Citation: Biology Direct 2025 20:3
    Content type: Research Published on:

  10. Multiple myeloma (MM) is a hematological malignancy characterized by uncontrolled proliferation of plasma cells and is currently incurable. Despite advancements in therapeutic strategies, resistance to proteas...

    Authors: Jin-Xing Wang, Ling Zhang, Peng-Wei Zhang, Luo-Wei Yuan, Jian Jiang, Xiao-Hui Cheng, Wei Zhu, Yong Lei and Fa-Qing Tian
    Citation: Biology Direct 2025 20:1
    Content type: Research Published on:

  11. Integrating multi-layered information can enhance the accuracy of genomic prediction for complex traits. However, the improvement and application of effective strategies for genomic prediction (GP) using multi...

    Authors: Zhida Zhao, Qunhao Niu, Jiayuan Wu, Tianyi Wu, Xueyuan Xie, Zezhao Wang, Lupei Zhang, Huijiang Gao, Xue Gao, Lingyang Xu, Bo Zhu and Junya Li
    Citation: Biology Direct 2024 19:147
    Content type: Research Published on:

  12. Prostate cancer is the most common diagnosed tumor and the fifth cancer related death among men in Europe. Although several genetic alterations such as ERG-TMPRSS2 fusion, MYC amplification, PTEN deletion and ...

    Authors: Massimiliano Agostini, Erica Giacobbi, Francesca Servadei, Julia Bishof, Likas Funke, Giuseppe Sica, Valentina Rovella, Marco Carilli, Valerio Iacovelli, Yufang Shi, Jianquan Hou, Eleonora Candi, Gerry Melino, Giulio Cervelli, Manuel Scimeca, Alessandro Mauriello…
    Citation: Biology Direct 2024 19:146
    Content type: Research Published on:

  13. Spermatogonial stem cells (SSCs) form haploid gametes through the precisely regulated process of spermatogenesis. Within the testis, SSCs undergo self-renewal through mitosis, differentiation, and then enter m...

    Authors: Xiuge Wang, Chunhong Yang, Xiaochao Wei, Yaran Zhang, Yao Xiao, Jinpeng Wang, Qiang Jiang, Zhihua Ju, Yaping Gao, Yanqin Li, Yundong Gao and Jinming Huang
    Citation: Biology Direct 2024 19:145
    Content type: Research Published on:

  14. Hepatocellular carcinoma (HCC) is the leading cause of cancer-related deaths worldwide, and the lack of effective biomarkers for early detection leads to poor therapeutic outcomes. Prostaglandin E Synthase 3 (...

    Authors: Shiwei Liu, Fukang Yuan, Hui Dong, Jiaqi Zhang, Xinyu Mao, Yangsui Liu and Huansong Li
    Citation: Biology Direct 2024 19:144
    Content type: Research Published on:

  15. Oral squamous cell carcinoma (OSCC) is the most frequent type of oral malignancy with high metastasis and poor prognosis. The deubiquitinating enzyme Ubiquitin Specific Peptidase 44 (USP44) regulates the mitot...

    Authors: Shuai Chen, Kefan Wu, Yingrui Zong, Zhenzhen Hou, Zhifen Deng and Zongping Xia
    Citation: Biology Direct 2024 19:143
    Content type: Research Published on:

  16. Intrauterine adhesion (IUA) is a common cause of clinically refractory infertility, and there exists significant heterogeneity in the treatment outcomes among IUA patients with the similar severity after trans...

    Authors: Yue Du, Ruzhen Shuai, Sang Luo, Yiran Jin, Fengjuan Xu, Jingyi Zhang, Dan Liu and Limin Feng
    Citation: Biology Direct 2024 19:142
    Content type: Research Published on:

  17. Alveolar macrophages (AMs) is critical to exacerbate acute lung injury (ALI) induced by lipopolysaccharide (LPS) via inhibiting inflammation, which could by shifted by mesenchymal stem cell-derived exosomes (M...

    Authors: Yanmei Wen and Zong’an Liang
    Citation: Biology Direct 2024 19:138
    Content type: Research Published on:

  18. Accumulating studies have focused on long noncoding RNAs (lncRNAs) because of their regulatory effects on multiple cancers. However, the biological functions and molecular mechanisms of lncRNAs in gastric canc...

    Authors: Xinyi Zhou, Cheng Gu, Linmei Xiao, Li Hu, Guanhua Chen, Fei Zuo, Hongan Shao and Bojian Fei
    Citation: Biology Direct 2024 19:137
    Content type: Research Published on:

  19. Clinically, phosphodiesterase type 5 inhibitors (PDE5-Is) remain the first-line therapy for erectile dysfunction (ED) patients; however, approximately 35% of these patients are still failing to respond to the ...

    Authors: Yi Wang, Guihua Chen and Deng Li
    Citation: Biology Direct 2024 19:136
    Content type: Comment Published on:

    The Correction to this article has been published in Biology Direct 2025 20:12

  20. Six-transmembrane epithelial antigen of prostate 3 (STEAP3) is associated with the progression of several human malignancies. However, its role in lung squamous cell carcinoma (LUSC) remains unclear. We measur...

    Authors: Tong Sun and Zhiguang Yang
    Citation: Biology Direct 2024 19:135
    Content type: Research Published on:

  21. In this work, we present a novel modeling framework for understanding the dynamics of homeostatic regulation. Inspired by engineering control theory, this framework incorporates unique features of biological s...

    Authors: Clemente F. Arias, Francisco J. Acosta, Federica Bertocchini and Cristina Fernández-Arias
    Citation: Biology Direct 2024 19:134
    Content type: Research Published on:

  22. This study explores the epigenetic mechanism of MLL1 regulating trophoblast ferroptosis in preeclampsia (PE). A murine model of PE was established, and HTR-8/SVneo cells were induced by Erastin to establish an...

    Authors: Lingling Li, Haining He, Zhenrong Zheng and Xiaolan Zhao
    Citation: Biology Direct 2024 19:133
    Content type: Research Published on:

  23. Precision oncology’s implementation in clinical practice faces significant constraints due to the inadequacies in tools for detailed patient stratification and personalized treatment methodologies. Dysregulate...

    Authors: Fan Li, Haiyi Hu, Liyang Li, Lifeng Ding, Zeyi Lu, Xudong Mao, Ruyue Wang, Wenqin Luo, Yudong Lin, Yang Li, Xianjiong Chen, Ziwei Zhu, Yi Lu, Chenghao Zhou, Mingchao Wang, Liqun Xia…
    Citation: Biology Direct 2024 19:132
    Content type: Research Published on:

  24. Peroxisome proliferator-activated receptor-γ (PPARγ) is a critical regulator of adipogenesis and bone metabolism, playing complex roles in osteoporosis. This study investigates the effects of taurine and homoc...

    Authors: Mazumder Adhish and I. Manjubala
    Citation: Biology Direct 2024 19:141
    Content type: Research Published on:

  27. Exosomes have emerged as significant biomarkers for multiple diseases, including cancers. Circular RNAs (circRNAs), abundant in exosomes, are involved in regulating cancer development. However, the regulatory ...

    Authors: Qing Meng, Haoyi Xiang, Yijing Wang, Kepeng Hu, Xin Luo, Jiawei Wang, Engeng Chen, Wei Zhang, Jiaxin Chen, Xiaoyu Chen, Huogang Wang, Zhenyu Ju and Zhangfa Song
    Citation: Biology Direct 2024 19:130
    Content type: Research Published on:

  28. UCHL5 was initially recognized as a multifunctional molecule. While recent research has highlighted its involvement in tumor malignant biological behaviors, its specific role in promoting tumor cell apoptosis ...

    Authors: Lingling Bao, Yuefei Wu, Zhengting Ren, Yi Huang, Yue Jiang, Kailang Li, Xin Xu, Yingquan Ye and Zhongxuan Gui
    Citation: Biology Direct 2024 19:139
    Content type: Research Published on:

  29. No authoritative books or guidelines are currently available for revealing the interrelationships of prostatitis, benign prostatic hyperplasia (BPH), and prostate cancer (PCa). Moreover, no consensus on this i...

    Authors: Yi Wang, Guihua Chen, Deng Li, Dongliang Zhang and Qianwei Xing
    Citation: Biology Direct 2024 19:129
    Content type: Research Published on:

  30. Disulfidptosis, identified as an innovative form of cellular death subsequent to cuproptosis, is currently under investigation for its mechanisms in oncological contexts. In-depth analyses exploring the relati...

    Authors: Tao Wang, Wenxuan Li, Yuelan Wu, Liping You, Chao Zheng, Jinghao Zhang, Lihong Qu and Xuehua Sun
    Citation: Biology Direct 2024 19:128
    Content type: Research Published on:

  31. MicroRNAs (miRNAs) have shown potential as diagnostic biomarkers for myocardial infarction (MI) due to their early dysregulation and stability in circulation after MI. Moreover, they play a crucial role in reg...

    Authors: Mehrdad Samadishadlou, Reza Rahbarghazi, Kaveh Kavousi and Farhad Bani
    Citation: Biology Direct 2024 19:127
    Content type: Research Published on:

  32. Mitochondria are highly dynamic organelles that constantly undergo processes of fission and fusion. The changes in mitochondrial dynamics shape the organellar morphology and influence cellular activity regulat...

    Authors: Wei-Ling Huang, Chang-Lin Chen, Zi-Jing Lin, Chia-Chun Hsieh, Mo Da-Sang Hua, Chih-Chan Cheng, Tzu-Hao Cheng, Lee-Jene Lai and Chuang-Rung Chang
    Citation: Biology Direct 2024 19:126
    Content type: Research Published on:

  33. Extrachromosomal circular DNAs (eccDNAs) are commonly found in various tumors and play a critical role in promoting oncogenesis. However, little is known about the characteristics and nature of eccDNAs in huma...

    Authors: Zhenhao Lin, Fangjie Dai, Bo Li, Yongchao Zhao and Changqian Wang
    Citation: Biology Direct 2024 19:125
    Content type: Research Published on:

  34. Here, we investigated the potential interaction between bromodomain-containing protein 4 (BRD4), an established epigenetic modulator and transcriptional coactivator, and p63, a member of the p53 transcription ...

    Authors: E. Foffi, A. Violante, R. Pecorari, A. M. Lena, F. Rugolo, G. Melino and E. Candi
    Citation: Biology Direct 2024 19:124
    Content type: Research Published on:

  35. Osteoporosis, a metabolic disorder, remains challenging to treat due to limited understanding of its underlying mechanism. The annual cycle of “cyclic physiological osteoporosis (CPO)” and its full reversal in...

    Authors: Chunyi Li, Wenying Wang, Guokun Zhang, Hengxing Ba, He Liu, Jincheng Wang, Wei Li, Gerry Melino and Yufang Shi
    Citation: Biology Direct 2024 19:123
    Content type: Review Published on:

  36. RNA methylation, an important reversible post-transcriptional modification in eukaryotes, has emerged as a prevalent epigenetic alteration. However, the role of the m6A reader YTH domain family 2 (YTHDF2) has ...

    Authors: Bao Dai, Lei Xu, Shikuo Rong, Muye Song, Ziteng Lan, Weijian Chen, Lingyun Zhang, Yongchen Liu, Linhe Wang, Jinghua Li, Jian Chen and Zeyu Wu
    Citation: Biology Direct 2024 19:122
    Content type: Research Published on:

  37. Preeclampsia (PE) is a severe pregnancy complication characterized by complex molecular interactions. Understanding these interactions is crucial for developing effective therapeutic strategies.

    Authors: Xiaohua Luo, Xiaopei Guo, Ningning Chen, Rui Peng, Ci Pan, Zhuyin Li, Bing Zhao, Ruonan Ji and Siyu Li
    Citation: Biology Direct 2024 19:121
    Content type: Research Published on:

  39. Telomeres are pivotal determinants of cell stemness, organismal aging, and lifespan. Herein, we examined similarities in telomeres of Arabidopsis thaliana, mice, and humans. We report the common traits, which inc...

    Authors: Edison Di Pietro, Romina Burla, Mattia La Torre, Mary-Paz González-García, Raffaele Dello Ioio and Isabella Saggio
    Citation: Biology Direct 2024 19:119
    Content type: Review Published on:

  40. Hepatocellular carcinoma (HCC) ranks among the most lethal malignancies around the world. However, the current management strategies for predicting prognosis in HCC patients remain unreliable. Our study develo...

    Authors: Hao Xu, Hui Pan, Lian Fang, Cangyuan Zhang, Chen Xiong and Weiti Cai
    Citation: Biology Direct 2024 19:118
    Content type: Research Published on:

  41. Sepsis is a severe condition characterized by multiple organ dysfunction resulting from an imbalanced host immune response to infections. miRNAs play a crucial role in regulating various biological processes. ...

    Authors: Yu Zhou, Yuan Yuan, Xuanqi Yao, Lin Wang, Liangfang Yao, Daolin Tang, Feng Chen and Jinbao Li
    Citation: Biology Direct 2024 19:117
    Content type: Research Published on:

  42. Tumor Mutational Burden (TMB) have emerged as pivotal predictive biomarkers in determining prognosis and response to immunotherapy in colorectal cancer (CRC) patients. While Whole Exome Sequencing (WES) stands...

    Authors: Yangyang Fang, Tianmei Fu, Qian Zhang, Ziqing Xiong, Kuai Yu and Aiping Le
    Citation: Biology Direct 2024 19:116
    Content type: Research Published on:

  43. Laryngeal cancer (LCA) is one of the most common head and neck squamous cell carcinoma with poor outcome. LCA stem cells are the main reason for LCA therapy resistance and relapse. Understanding the molecular ...

    Authors: Wenlin Liu, Jie Wu, Yuanpu Lai, Siyi Zhang, Ankui Yang, Yixuan Li, Cuifang Chen and Zhongming Lu
    Citation: Biology Direct 2024 19:115
    Content type: Research Published on:

  45. Gliomas represent a highly aggressive class of tumors located in the brain. Despite the availability of multiple treatment modalities, the prognosis for patients diagnosed with glioma remains unfavorable. Ther...

    Authors: Suyin Feng, Long Zhu, Yan Qin, Kun Kou, Yongtai Liu, Guangmin Zhang, Ziheng Wang, Hua Lu and Runfeng Sun
    Citation: Biology Direct 2024 19:113
    Content type: Research Published on:

  46. Precise regulation of gene expression is crucial to development. Enhancers, the core of gene regulation, determine the spatiotemporal pattern of gene transcription. Since many disease-associated mutations are ...

    Authors: Junyou Zhang, Qilin Wang, Jiaxin Liu, Yingying Duan, Zhaoshuo Liu, Ziyi Zhang and Chunyan Li
    Citation: Biology Direct 2024 19:112
    Content type: Review Published on:

  47. Dysregulated androgen receptor (AR) activity is central to various diseases, particularly prostate cancer (PCa), in which it drives tumour initiation and progression. Consequently, antagonising AR activity via...

    Authors: Justus S. Israel, Laura-Maria Marcelin, Sherif Mehralivand, Jana Scholze, Jörg Hofmann, Matthias B. Stope, Martin Puhr, Christian Thomas and Holger H. H. Erb
    Citation: Biology Direct 2024 19:111
    Content type: Research Published on:

  48. Hepatocellular carcinoma (HCC) is one of the most common as well as leading causes of mortality worldwide, and sorafenib is the first-line treatment in HCC patients. Unfortunately, drug resistance to sorafenib...

    Authors: Xiangbo Huang, Nan Yi, Pengfei Zhu, Jian Gao and Jun Lv
    Citation: Biology Direct 2024 19:110
    Content type: Research Published on:

  49. MicroRNAs (miRNAs) are critical regulators of cancer progression, prompting our investigation into the specific function of miR-630 in pancreatic cancer stem cells (PCSCs). Analysis of miRNA and mRNA expressio...

    Authors: Jun Zou, Sha Yang, Chongwu He, Lei Deng, Bangran Xu and Shuai Chen
    Citation: Biology Direct 2024 19:109
    Content type: Research Published on:
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